PGD [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PGD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGD
  * **<color #00a2e8>Official Name</color>**: phosphogluconate dehydrogenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5226|5226]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52209|P52209]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172200|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|6PGD|
|NAD binding 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphogluconate dehydrogenase (decarboxylating) activity|
|D-gluconate catabolic process|
|aldonic acid metabolic process|
|aldonic acid catabolic process|
|D-gluconate metabolic process|
|pentose-phosphate shunt, oxidative branch|
|pentose biosynthetic process|
|pentose-phosphate shunt|
|pentose metabolic process|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|NADP binding|
|cellular carbohydrate catabolic process|
|monosaccharide biosynthetic process|
|monocarboxylic acid catabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|cellular carbohydrate metabolic process|
|monosaccharide metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|small molecule biosynthetic process|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.84|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.76|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.77|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.88|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 465/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|14/28|
|blood|24/28|
|bone|11/26|
|breast|27/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|10/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|13/16|
|kidney|16/21|
|liver|10/20|
|lung|55/75|
|lymphocyte|14/16|
|ovary|14/26|
|pancreas|17/24|
|peripheral nervous system|8/16|
|plasma cell|14/15|
|prostate|0/1|
|skin|20/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 123
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGD Expression in NALM6 Cells: 7.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>