PGLS [The Human Chemical-Genetic Interaction Map Project]

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======= PGLS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGLS
  * **<color #00a2e8>Official Name</color>**: 6-phosphogluconolactonase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25796|25796]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95336|O95336]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGLS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGLS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Glucosamine iso|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|6-phosphogluconolactonase activity|
|pentose-phosphate shunt, oxidative branch|
|pentose-phosphate shunt|
|NADPH regeneration|
|glucose 6-phosphate metabolic process|
|NADP metabolic process|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|organophosphate metabolic process|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.74|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.79|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.97|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.97|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.08|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.16|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.35|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.46|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|3.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgp|PGP]]|0.569|
|[[:human genes:h:hk2|HK2]]|0.562|
|[[:human genes:g:gpi|GPI]]|0.514|
|[[:human genes:r:rpe|RPE]]|0.471|
|[[:human genes:t:tkt|TKT]]|0.463|
|[[:human genes:p:pfkp|PFKP]]|0.461|
|[[:human genes:r:romo1|ROMO1]]|0.456|
|[[:human genes:d:dnlz|DNLZ]]|0.445|
|[[:human genes:t:timm8b|TIMM8B]]|0.439|
|[[:human genes:c:crls1|CRLS1]]|0.407|
|[[:human genes:c:coq3|COQ3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2583
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGLS Expression in NALM6 Cells: 4.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>