PGLYRP1 [The Human Chemical-Genetic Interaction Map Project]

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======= PGLYRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGLYRP1
  * **<color #00a2e8>Official Name</color>**: peptidoglycan recognition protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8993|8993]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75594|O75594]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGLYRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGLYRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604963|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. {ECO:0000269|PubMed:11461926, ECO:0000269|PubMed:16354652}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amidase 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth of symbiont in host|
|growth involved in symbiotic interaction|
|positive regulation of cytolysis in other organism|
|N-acetylmuramoyl-L-alanine amidase activity|
|negative regulation of natural killer cell differentiation involved in immune response|
|phagocytic vesicle lumen|
|regulation of cytolysis in other organism|
|negative regulation of natural killer cell differentiation|
|regulation of natural killer cell differentiation involved in immune response|
|peptidoglycan receptor activity|
|peptidoglycan metabolic process|
|peptidoglycan catabolic process|
|negative regulation of natural killer cell activation|
|positive regulation of cytolysis|
|detection of bacterium|
|regulation of natural killer cell differentiation|
|detection of other organism|
|positive regulation of killing of cells of other organism|
|peptidoglycan binding|
|regulation of cytolysis|
|regulation of killing of cells of other organism|
|detection of external biotic stimulus|
|detection of biotic stimulus|
|regulation of natural killer cell activation|
|negative regulation of interferon-gamma production|
|killing of cells of other organism|
|disruption of cells of other organism|
|negative regulation of lymphocyte differentiation|
|tertiary granule lumen|
|glycosaminoglycan catabolic process|
|specific granule lumen|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|aminoglycan catabolic process|
|positive regulation of cell killing|
|cell killing|
|defense response to Gram-positive bacterium|
|regulation of interferon-gamma production|
|negative regulation of leukocyte differentiation|
|regulation of cell killing|
|antimicrobial humoral response|
|negative regulation of immune effector process|
|pattern recognition receptor signaling pathway|
|negative regulation of inflammatory response|
|negative regulation of hemopoiesis|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|glycosaminoglycan metabolic process|
|modification of morphology or physiology of other organism|
|aminoglycan metabolic process|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|carbohydrate derivative catabolic process|
|negative regulation of cell activation|
|negative regulation of defense response|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|defense response to bacterium|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|humoral immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|growth|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|positive regulation of multi-organism process|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|detection of stimulus|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|negative regulation of cell differentiation|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|exocytosis|
|interspecies interaction between organisms|
|zinc ion binding|
|positive regulation of immune response|
|leukocyte activation|
|negative regulation of developmental process|
|defense response to other organism|
|secretion by cell|
|carbohydrate derivative metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|organic substance catabolic process|
|regulation of cell differentiation|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.79|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.74|
|[[:results:exp303|39°C R06 exp303]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.675|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGLYRP1 Expression in NALM6 Cells: -1.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>