PGR [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PGR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGR
  * **<color #00a2e8>Official Name</color>**: progesterone receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5241|5241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06401|P06401]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. {ECO:0000269|PubMed:10757795, ECO:0000269|PubMed:1587864, ECO:0000269|PubMed:9407067, ECO:0000305}. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. {ECO:0000269|PubMed:7969170}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
|Prog receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tertiary branching involved in mammary gland duct morphogenesis|
|mammary gland branching involved in pregnancy|
|paracrine signaling|
|progesterone receptor signaling pathway|
|ovulation from ovarian follicle|
|epithelial cell maturation|
|ovulation|
|branching involved in mammary gland duct morphogenesis|
|steroid binding|
|mammary gland duct morphogenesis|
|lung alveolus development|
|ovulation cycle process|
|mammary gland morphogenesis|
|nuclear receptor activity|
|steroid hormone receptor activity|
|mammary gland epithelium development|
|maternal process involved in female pregnancy|
|ovulation cycle|
|intracellular steroid hormone receptor signaling pathway|
|ATPase binding|
|female gonad development|
|development of primary female sexual characteristics|
|gland morphogenesis|
|female sex differentiation|
|steroid hormone mediated signaling pathway|
|mammary gland development|
|female gamete generation|
|branching morphogenesis of an epithelial tube|
|anatomical structure maturation|
|cell maturation|
|morphogenesis of a branching epithelium|
|mitochondrial outer membrane|
|intracellular receptor signaling pathway|
|morphogenesis of a branching structure|
|lung development|
|hormone-mediated signaling pathway|
|respiratory tube development|
|transcription initiation from RNA polymerase II promoter|
|female pregnancy|
|cellular response to steroid hormone stimulus|
|epithelial cell development|
|respiratory system development|
|gonad development|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|DNA-templated transcription, initiation|
|developmental maturation|
|sex differentiation|
|rhythmic process|
|epithelial tube morphogenesis|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|enzyme binding|
|gland development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|transcription by RNA polymerase II|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|multi-organism reproductive process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|cell-cell signaling|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|DNA binding|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGR Expression in NALM6 Cells: -1.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>