PGS1 [The Human Chemical-Genetic Interaction Map Project]

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======= PGS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGS1
  * **<color #00a2e8>Official Name</color>**: phosphatidylglycerophosphate synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9489|9489]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q32NB8|Q32NB8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614942|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|
|cardiolipin biosynthetic process|
|phosphatidylglycerol biosynthetic process|
|cardiolipin metabolic process|
|diacylglycerol metabolic process|
|phosphatidylglycerol metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|mitochondrial inner membrane|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|calcium ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|lipid metabolic process|
|mitochondrion|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.75|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.72|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|1.73|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.76|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.82|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnlz|DNLZ]]|0.581|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.507|
|[[:human genes:t:tamm41|TAMM41]]|0.503|
|[[:human genes:t:triap1|TRIAP1]]|0.488|
|[[:human genes:t:thg1l|THG1L]]|0.476|
|[[:human genes:t:trmt61a|TRMT61A]]|0.475|
|[[:human genes:r:romo1|ROMO1]]|0.471|
|[[:human genes:d:dhrsx|DHRSX]]|0.467|
|[[:human genes:p:pmvk|PMVK]]|0.465|
|[[:human genes:r:rpia|RPIA]]|0.461|
|[[:human genes:d:dohh|DOHH]]|0.457|
|[[:human genes:a:atp5a1|ATP5A1]]|0.455|
|[[:human genes:t:ten1|TEN1]]|0.448|
|[[:human genes:c:cep57|CEP57]]|0.433|
|[[:human genes:a:atxn10|ATXN10]]|0.431|
|[[:human genes:p:ppcs|PPCS]]|0.429|
|[[:human genes:p:pgm3|PGM3]]|0.427|
|[[:human genes:p:pars2|PARS2]]|0.425|
|[[:human genes:s:srd5a3|SRD5A3]]|0.419|
|[[:human genes:a:alg8|ALG8]]|0.419|
|[[:human genes:f:fastkd5|FASTKD5]]|0.418|
|[[:human genes:s:srp14|SRP14]]|0.416|
|[[:human genes:a:atp5d|ATP5D]]|0.414|
|[[:human genes:k:kdsr|KDSR]]|0.413|
|[[:human genes:t:taz|TAZ]]|0.411|
|[[:human genes:m:mrps6|MRPS6]]|0.411|
|[[:human genes:b:bcs1l|BCS1L]]|0.409|
|[[:human genes:f:fh|FH]]|0.407|
|[[:human genes:c:crls1|CRLS1]]|0.406|
|[[:human genes:p:ppcdc|PPCDC]]|0.405|
|[[:human genes:c:cept1|CEPT1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 485/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|18/28|
|blood|16/28|
|bone|12/26|
|breast|20/33|
|central nervous system|42/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|11/21|
|liver|14/20|
|lung|50/75|
|lymphocyte|9/16|
|ovary|15/26|
|pancreas|19/24|
|peripheral nervous system|7/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|23/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGS1 Expression in NALM6 Cells: 5.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>