PHF16 [The Human Chemical-Genetic Interaction Map Project]

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======= PHF16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: JADE3
  * **<color #00a2e8>Official Name</color>**: jade family PHD finger 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9767|9767]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92613|Q92613]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300618|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of large proteins containing PHD (plant homeo domain)-type zinc fingers. The encoded protein may be associated in a nuclear complex that functions in histone H4 acetylation. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. {ECO:0000269|PubMed:16387653}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EPL1|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H4-K12 acetylation|
|histone H4-K8 acetylation|
|histone H4-K5 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|histone H3 acetylation|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|chromatin organization|
|peptidyl-amino acid modification|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.75|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.91|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.92|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.18|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.39|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2817
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF16 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>