PHF8 [The Human Chemical-Genetic Interaction Map Project]

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======= PHF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PHF8
  * **<color #00a2e8>Official Name</color>**: PHD finger protein 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23133|23133]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPP1|Q9UPP1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PHF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PHF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. The protein has an N-terminal PHD finger and a central Jumonji C domain. This gene is thought to function as a transcription activator. Defects in this gene are a cause of syndromic X-linked Siderius type intellectual disability (MRXSSD) and over-expression of this gene is associated with several forms of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|JmjC|
|PHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H4-K20 demethylation|
|negative regulation of chromatin silencing at rDNA|
|histone demethylase activity (H4-K20 specific)|
|regulation of chromatin silencing at rDNA|
|histone demethylase activity (H3-K27 specific)|
|histone H3-K27 demethylation|
|histone H3-K36 demethylation|
|histone demethylase activity (H3-K36 specific)|
|histone demethylase activity (H3-K9 specific)|
|histone demethylase activity|
|histone H3-K9 demethylation|
|2-oxoglutarate-dependent dioxygenase activity|
|negative regulation of chromatin silencing|
|positive regulation of transcription by RNA polymerase I|
|histone lysine demethylation|
|histone demethylation|
|protein dealkylation|
|protein demethylation|
|regulation of transcription by RNA polymerase I|
|negative regulation of gene silencing|
|regulation of chromatin silencing|
|negative regulation of chromatin organization|
|methylated histone binding|
|positive regulation of gene expression, epigenetic|
|demethylation|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|regulation of gene silencing|
|iron ion binding|
|negative regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of gene expression, epigenetic|
|nuclear membrane|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|regulation of chromosome organization|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|chromatin binding|
|mitotic cell cycle process|
|mitotic cell cycle|
|chromatin organization|
|negative regulation of cellular component organization|
|brain development|
|head development|
|zinc ion binding|
|nucleolus|
|oxidation-reduction process|
|central nervous system development|
|cell cycle process|
|chromosome organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.46|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.04|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.98|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.96|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.95|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.83|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.78|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.77|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.73|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.79|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.97|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.46|
|[[:human genes:u:ube2q1|UBE2Q1]]|0.426|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10263
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PHF8 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>