PIDD [The Human Chemical-Genetic Interaction Map Project]

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======= PIDD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIDD1
  * **<color #00a2e8>Official Name</color>**: p53-induced death domain protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55367|55367]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB75|Q9HB75]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIDD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIDD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605247|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Death|
|Peptidase S68|
|ZU5|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|volume-sensitive anion channel activity|
|ion channel complex|
|death receptor binding|
|protein autoprocessing|
|extrinsic apoptotic signaling pathway via death domain receptors|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA integrity checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|mitotic G1 DNA damage checkpoint|
|mitotic G1/S transition checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|endopeptidase activity|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitotic DNA damage checkpoint|
|extrinsic apoptotic signaling pathway|
|negative regulation of G1/S transition of mitotic cell cycle|
|mitotic DNA integrity checkpoint|
|signal transduction in response to DNA damage|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|DNA damage checkpoint|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|DNA integrity checkpoint|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|mitotic cell cycle checkpoint|
|protein processing|
|inorganic anion transport|
|regulation of cell cycle G1/S phase transition|
|positive regulation of endopeptidase activity|
|positive regulation of peptidase activity|
|cell cycle checkpoint|
|negative regulation of mitotic cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|protein maturation|
|negative regulation of cell cycle phase transition|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of DNA-binding transcription factor activity|
|anion transmembrane transport|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|positive regulation of proteolysis|
|positive regulation of cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|anion transport|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|ion transmembrane transport|
|Golgi apparatus|
|negative regulation of cell death|
|cell cycle process|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|proteolysis|
|regulation of hydrolase activity|
|transmembrane transport|
|cell cycle|
|ion transport|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.7|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.7|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|5.81|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|6.5|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|6.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cradd|CRADD]]|0.758|
|[[:human genes:c:c2cd3|C2CD3]]|0.722|
|[[:human genes:k:kiaa0753|KIAA0753]]|0.707|
|[[:human genes:o:odf2|ODF2]]|0.693|
|[[:human genes:c:c16orf59|C16orf59]]|0.659|
|[[:human genes:c:casp2|CASP2]]|0.655|
|[[:human genes:a:ankrd26|ANKRD26]]|0.654|
|[[:human genes:p:pibf1|PIBF1]]|0.653|
|[[:human genes:o:ofd1|OFD1]]|0.644|
|[[:human genes:c:c14orf80|C14orf80]]|0.637|
|[[:human genes:c:ccdc41|CCDC41]]|0.621|
|[[:human genes:n:nin|NIN]]|0.609|
|[[:human genes:c:cep120|CEP120]]|0.606|
|[[:human genes:c:cep76|CEP76]]|0.588|
|[[:human genes:c:cep128|CEP128]]|0.577|
|[[:human genes:t:tubd1|TUBD1]]|0.563|
|[[:human genes:f:fopnl|FOPNL]]|0.557|
|[[:human genes:r:rttn|RTTN]]|0.554|
|[[:human genes:s:sclt1|SCLT1]]|0.547|
|[[:human genes:t:tube1|TUBE1]]|0.512|
|[[:human genes:c:cep78|CEP78]]|0.511|
|[[:human genes:c:cep44|CEP44]]|0.494|
|[[:human genes:h:hyls1|HYLS1]]|0.493|
|[[:human genes:i:ipp|IPP]]|0.435|
|[[:human genes:p:ppp1r35|PPP1R35]]|0.432|
|[[:human genes:c:cep152|CEP152]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3112
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIDD Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>