PIGO [The Human Chemical-Genetic Interaction Map Project]

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======= PIGO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIGO
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol glycan anchor biosynthesis class O
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84720|84720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEQ8|Q8TEQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIGO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIGO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. {ECO:0000269|PubMed:24049131, ECO:0000269|PubMed:28337824}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metalloenzyme|
|Phosphodiest|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mannose-ethanolamine phosphotransferase activity|
|GPI anchor biosynthetic process|
|GPI anchor metabolic process|
|glycolipid biosynthetic process|
|protein lipidation|
|lipoprotein biosynthetic process|
|phosphatidylinositol biosynthetic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|lipoprotein metabolic process|
|membrane lipid biosynthetic process|
|phosphatidylinositol metabolic process|
|membrane lipid metabolic process|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.37|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.12|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.74|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.87|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.92|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.96|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.02|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.13|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.21|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.25|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.35|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.47|
|[[:results:exp360|Genistein 15μM R07 exp360]]|3.07|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp1a1|ATP1A1]]|0.635|
|[[:human genes:t:tmem161b|TMEM161B]]|0.592|
|[[:human genes:p:pigf|PIGF]]|0.48|
|[[:human genes:n:ndrg3|NDRG3]]|0.458|
|[[:human genes:a:atp1b3|ATP1B3]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2150
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIGO Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>