PIK3CA [The Human Chemical-Genetic Interaction Map Project]

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======= PIK3CA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIK3CA
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5290|5290]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42336|P42336]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIK3CA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIK3CA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/171834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity). {ECO:0000250|UniProtKB:P42337, ECO:0000269|PubMed:21708979, ECO:0000269|PubMed:26593112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PI3K p85B|
|PI3K rbd|
|PI3K C2|
|PI3 PI4 kinase|
|PI3Ka|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylinositol 3-kinase complex, class IA|
|hypomethylation of CpG island|
|DNA hypomethylation|
|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|
|regulation of genetic imprinting|
|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|
|phosphatidylinositol 3-kinase activity|
|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|
|negative regulation of fibroblast apoptotic process|
|1-phosphatidylinositol-4-phosphate 3-kinase activity|
|1-phosphatidylinositol-3-kinase activity|
|anoikis|
|insulin receptor substrate binding|
|phosphatidylinositol-3-phosphate biosynthetic process|
|negative regulation of anoikis|
|regulation of fibroblast apoptotic process|
|phosphatidylinositol 3-kinase complex|
|regulation of anoikis|
|regulation of DNA methylation|
|protein kinase activator activity|
|regulation of cellular respiration|
|ERBB2 signaling pathway|
|phosphatidylinositol 3-kinase signaling|
|negative regulation of macroautophagy|
|energy homeostasis|
|adipose tissue development|
|protein kinase B signaling|
|positive regulation of TOR signaling|
|epidermal growth factor receptor signaling pathway|
|phosphatidylinositol phosphorylation|
|T cell costimulation|
|lymphocyte costimulation|
|lipid phosphorylation|
|endothelial cell migration|
|regulation of multicellular organism growth|
|vascular endothelial growth factor receptor signaling pathway|
|cellular response to glucose stimulus|
|ERBB signaling pathway|
|cellular response to hexose stimulus|
|phosphatidylinositol-mediated signaling|
|cellular response to monosaccharide stimulus|
|inositol lipid-mediated signaling|
|cardiac muscle contraction|
|cellular response to carbohydrate stimulus|
|kinase activity|
|epithelial cell migration|
|negative regulation of autophagy|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|epithelium migration|
|heart contraction|
|cellular glucose homeostasis|
|insulin receptor signaling pathway|
|tissue migration|
|heart process|
|regulation of TOR signaling|
|positive regulation of peptidyl-serine phosphorylation|
|phosphatidylinositol biosynthetic process|
|striated muscle contraction|
|glucose metabolic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|liver development|
|hepaticobiliary system development|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|regulation of peptidyl-serine phosphorylation|
|response to glucose|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|response to hexose|
|negative regulation of neuron apoptotic process|
|response to monosaccharide|
|hexose metabolic process|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|positive regulation of protein kinase B signaling|
|phosphatidylinositol metabolic process|
|ameboidal-type cell migration|
|response to carbohydrate|
|regulation of macroautophagy|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|lamellipodium|
|glucose homeostasis|
|carbohydrate homeostasis|
|monosaccharide metabolic process|
|lipid modification|
|positive regulation of T cell activation|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|glycerophospholipid biosynthetic process|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of protein kinase B signaling|
|glycerolipid biosynthetic process|
|connective tissue development|
|response to insulin|
|Fc receptor signaling pathway|
|phospholipid biosynthetic process|
|muscle contraction|
|negative regulation of cellular catabolic process|
|positive regulation of cell-cell adhesion|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|hemostasis|
|muscle system process|
|glycerophospholipid metabolic process|
|negative regulation of catabolic process|
|regulation of neuron death|
|angiogenesis|
|regulation of T cell activation|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|regulation of developmental growth|
|phagocytosis|
|regulation of autophagy|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|protein serine/threonine kinase activity|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|leukocyte migration|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|blood vessel morphogenesis|
|axon development|
|gland development|
|positive regulation of cell activation|
|cell morphogenesis involved in neuron differentiation|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|carbohydrate metabolic process|
|wound healing|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cell part morphogenesis|
|regulation of lymphocyte activation|
|cardiovascular system development|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|response to wounding|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|activation of immune response|
|regulation of cell activation|
|tube morphogenesis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of protein kinase activity|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|response to hormone|
|apoptotic process|
|cellular lipid metabolic process|
|cell migration|
|protein phosphorylation|
|regulation of transferase activity|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|immune effector process|
|cell death|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.77|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15017
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIK3CA Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>