PIP4K2B [The Human Chemical-Genetic Interaction Map Project]

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======= PIP4K2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIP4K2B
  * **<color #00a2e8>Official Name</color>**: phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8396|8396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P78356|P78356]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIP4K2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIP4K2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:9038203}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PIP5K|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-5-phosphate 4-kinase activity|
|1-phosphatidylinositol-4-phosphate 5-kinase activity|
|positive regulation of autophagosome assembly|
|positive regulation of vacuole organization|
|regulation of autophagosome assembly|
|regulation of vacuole organization|
|phosphatidylinositol phosphorylation|
|lipid phosphorylation|
|positive regulation of macroautophagy|
|autophagosome|
|positive regulation of organelle assembly|
|phosphatidylinositol biosynthetic process|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|phosphatidylinositol metabolic process|
|regulation of macroautophagy|
|lipid modification|
|glycerophospholipid biosynthetic process|
|regulation of organelle assembly|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|positive regulation of catabolic process|
|positive regulation of cellular component biogenesis|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|positive regulation of organelle organization|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|phosphorylation|
|regulation of organelle organization|
|ATP binding|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.7|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.75|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.78|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.472|
|[[:human genes:p:polr2j3|POLR2J3]]|0.441|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3561
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIP4K2B Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>