PIWIL2 [The Human Chemical-Genetic Interaction Map Project]

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======= PIWIL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PIWIL2
  * **<color #00a2e8>Official Name</color>**: piwi like RNA-mediated gene silencing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55124|55124]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TC59|Q8TC59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PIWIL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PIWIL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610312|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Piwi|
|PAZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|perinucleolar chromocenter|
|PET complex|
|germ-line stem cell population maintenance|
|piRNA binding|
|positive regulation of histone H3-K14 acetylation|
|positive regulation of meiosis I|
|piRNA biosynthetic process|
|polysome binding|
|regulation of histone H3-K14 acetylation|
|dense body|
|pi-body|
|regulation of meiosis I|
|positive regulation of histone H3-K9 acetylation|
|chromatoid body|
|regulation of histone H3-K9 acetylation|
|positive regulation of meiotic nuclear division|
|negative regulation of circadian rhythm|
|P granule|
|piRNA metabolic process|
|DNA methylation involved in gamete generation|
|RNA 5-end processing|
|negative regulation of transposition|
|regulation of transposition|
|positive regulation of meiotic cell cycle|
|endoribonuclease activity|
|positive regulation of histone acetylation|
|regulation of meiotic nuclear division|
|positive regulation of peptidyl-lysine acetylation|
|positive regulation of protein acetylation|
|DNA alkylation|
|DNA methylation|
|regulation of meiotic cell cycle|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|DNA methylation or demethylation|
|positive regulation of nuclear division|
|regulation of protein acetylation|
|oogenesis|
|positive regulation of reproductive process|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|gene silencing by RNA|
|DNA modification|
|positive regulation of histone modification|
|positive regulation of chromatin organization|
|regulation of circadian rhythm|
|positive regulation of translation|
|female gamete generation|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of histone modification|
|positive regulation of cellular amide metabolic process|
|gene silencing|
|RNA phosphodiester bond hydrolysis|
|regulation of reproductive process|
|mRNA binding|
|positive regulation of chromosome organization|
|regulation of chromatin organization|
|regulation of nuclear division|
|meiotic cell cycle|
|macromolecule methylation|
|germ cell development|
|rhythmic process|
|positive regulation of cell cycle process|
|nucleic acid phosphodiester bond hydrolysis|
|methylation|
|regulation of chromosome organization|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cell cycle|
|regulation of cellular amide metabolic process|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|positive regulation of organelle organization|
|developmental process involved in reproduction|
|gamete generation|
|DNA metabolic process|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|RNA processing|
|multi-organism reproductive process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|positive regulation of cellular protein metabolic process|
|cell development|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6378
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PIWIL2 Expression in NALM6 Cells: 1.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>