PKD1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= PKD1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKD1L1
  * **<color #00a2e8>Official Name</color>**: polycystin 1 like 1, transient receptor potential channel interacting
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=168507|168507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDX9|Q8TDX9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKD1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKD1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the polycystin protein family containing 11 transmembrane domains, a receptor for egg jelly (REJ) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. The encoded protein may play a role in the male reproductive system. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:24336289}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PLAT|
|REJ|
|PKD|
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of nodal flow|
|detection of endogenous stimulus|
|left/right axis specification|
|left/right pattern formation|
|calcium channel complex|
|non-motile cilium|
|detection of mechanical stimulus|
|calcium channel activity|
|ciliary membrane|
|axis specification|
|determination of left/right symmetry|
|detection of external stimulus|
|detection of abiotic stimulus|
|determination of bilateral symmetry|
|specification of symmetry|
|calcium ion transmembrane transport|
|cilium|
|response to mechanical stimulus|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regionalization|
|pattern specification process|
|cell-cell adhesion|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|cation transport|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.9|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.92|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.06|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.21|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5416
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKD1L1 Expression in NALM6 Cells: -1.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>