PKD1L3 [The Human Chemical-Genetic Interaction Map Project]

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======= PKD1L3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKD1L3
  * **<color #00a2e8>Official Name</color>**: polycystin 1 like 3, transient receptor potential channel interacting
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=342372|342372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z443|Q7Z443]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKD1L3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKD1L3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. {ECO:0000269|PubMed:12782129, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GPS|
|PLAT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of chemical stimulus involved in sensory perception of sour taste|
|sour taste receptor activity|
|sensory perception of sour taste|
|cation transmembrane transporter activity|
|cation channel complex|
|cellular response to acidic pH|
|cation channel activity|
|response to acidic pH|
|cellular response to pH|
|response to pH|
|detection of mechanical stimulus|
|detection of chemical stimulus involved in sensory perception of taste|
|calcium channel activity|
|sensory perception of taste|
|detection of external stimulus|
|detection of abiotic stimulus|
|carbohydrate binding|
|calcium ion transmembrane transport|
|receptor complex|
|response to mechanical stimulus|
|calcium ion transport|
|kidney development|
|renal system development|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|urogenital system development|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|cation transport|
|ion transmembrane transport|
|sensory perception|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.91|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.01|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12718
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKD1L3 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>