PKMYT1 [The Human Chemical-Genetic Interaction Map Project]

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======= PKMYT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PKMYT1
  * **<color #00a2e8>Official Name</color>**: protein kinase, membrane associated tyrosine/threonine 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9088|9088]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99640|Q99640]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PKMYT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PKMYT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602474|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinase activity|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|regulation of mitotic nuclear division|
|regulation of phosphatase activity|
|regulation of nuclear division|
|regulation of dephosphorylation|
|meiotic cell cycle|
|protein kinase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|protein serine/threonine kinase activity|
|negative regulation of hydrolase activity|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|mitotic cell cycle process|
|Golgi membrane|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|nucleolus|
|regulation of kinase activity|
|endoplasmic reticulum membrane|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|cell cycle process|
|endoplasmic reticulum|
|negative regulation of molecular function|
|regulation of cell cycle|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.42|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.44|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.41|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.18|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.94|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.88|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.82|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.72|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.77|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.99|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.05|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.32|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.03|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|4.28|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 456/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|18/28|
|bone|12/26|
|breast|21/33|
|central nervous system|36/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|9/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|15/21|
|liver|14/20|
|lung|39/75|
|lymphocyte|11/16|
|ovary|16/26|
|pancreas|20/24|
|peripheral nervous system|11/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|14/22|
|urinary tract|19/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1524
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PKMYT1 Expression in NALM6 Cells: 6.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>