PLA2G16 [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLAAT3
  * **<color #00a2e8>Official Name</color>**: phospholipase A and acyltransferase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11145|11145]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53816|P53816]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613867|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). Shows phospholipase A1 and A2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity (PubMed:19047760). Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity). May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines (PubMed:22605381, PubMed:25383759). The relevance of acyltransferase activity in vivo is however unclear and would require additional evidences (PubMed:22605381, PubMed:25383759). Also has weak lysophospholipase activity (By similarity). {ECO:0000250|UniProtKB:Q8R3U1, ECO:0000269|PubMed:17374643, ECO:0000269|PubMed:19047760, ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:20837014, ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22923616, ECO:0000269|PubMed:25383759}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-acyl-2-lysophosphatidylserine acylhydrolase activity|
|N-acylphosphatidylethanolamine metabolic process|
|phosphatidylserine 1-acylhydrolase activity|
|N-acyltransferase activity|
|phospholipase A1 activity|
|regulation of adipose tissue development|
|ether lipid metabolic process|
|glycerol ether metabolic process|
|phosphatidylinositol acyl-chain remodeling|
|ether metabolic process|
|phosphatidylserine acyl-chain remodeling|
|phosphatidylethanolamine metabolic process|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|phospholipase A2 activity|
|phosphatidylserine metabolic process|
|peroxisomal membrane|
|triglyceride metabolic process|
|phosphatidylcholine metabolic process|
|peroxisome organization|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|peroxisome|
|phosphatidylinositol metabolic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|phospholipid biosynthetic process|
|lipid catabolic process|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|cellular component|
|organophosphate biosynthetic process|
|negative regulation of cell cycle|
|lipid biosynthetic process|
|response to bacterium|
|perinuclear region of cytoplasm|
|cellular amide metabolic process|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|endoplasmic reticulum|
|regulation of cell cycle|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|small molecule metabolic process|
|organic substance catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8153
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G16 Expression in NALM6 Cells: 0.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>