PLA2G1B [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G1B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G1B
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IB
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5319|5319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04054|P04054]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G1B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G1B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. {ECO:0000269|PubMed:19297324}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of phospholipase A2 activity|
|positive regulation of phospholipase A2 activity|
|bile acid binding|
|interleukin-8 production|
|regulation of phospholipase A2 activity|
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|innate immune response in mucosa|
|leukotriene biosynthetic process|
|phosphatidylserine acyl-chain remodeling|
|arachidonate transport|
|arachidonic acid secretion|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phospholipase A2 activity|
|mucosal immune response|
|phosphatidylglycerol metabolic process|
|phosphatidylserine metabolic process|
|icosanoid transport|
|fatty acid derivative transport|
|leukotriene metabolic process|
|organ or tissue specific immune response|
|antibacterial humoral response|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|icosanoid biosynthetic process|
|positive regulation of fibroblast proliferation|
|positive regulation of calcium ion transport into cytosol|
|regulation of glucose import|
|long-chain fatty acid transport|
|positive regulation of phospholipase activity|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|fatty acid transport|
|regulation of glucose transmembrane transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|regulation of fibroblast proliferation|
|neutrophil chemotaxis|
|secretory granule|
|granulocyte chemotaxis|
|fatty acid derivative biosynthetic process|
|neutrophil migration|
|defense response to Gram-positive bacterium|
|regulation of lipase activity|
|regulation of calcium ion transport into cytosol|
|granulocyte migration|
|phospholipid binding|
|antimicrobial humoral response|
|icosanoid metabolic process|
|fatty acid biosynthetic process|
|positive regulation of calcium ion transport|
|myeloid leukocyte migration|
|monocarboxylic acid transport|
|leukocyte chemotaxis|
|cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|activation of MAPK activity|
|cellular response to insulin stimulus|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|monocarboxylic acid biosynthetic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|cell chemotaxis|
|glycerolipid biosynthetic process|
|response to insulin|
|actin filament organization|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|cellular response to peptide hormone stimulus|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|cellular response to peptide|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|defense response to bacterium|
|signaling receptor binding|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|humoral immune response|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|leukocyte migration|
|regulation of metal ion transport|
|response to peptide hormone|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of DNA-binding transcription factor activity|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|regulation of peptide secretion|
|neutrophil mediated immunity|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|actin filament-based process|
|positive regulation of kinase activity|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|response to bacterium|
|regulation of ion transport|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|innate immune response|
|positive regulation of hydrolase activity|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|cellular homeostasis|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|defense response to other organism|
|cellular lipid metabolic process|
|cell migration|
|regulation of transferase activity|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|immune effector process|
|cytoskeleton organization|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|ion transport|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.07|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.99|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.72|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G1B Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>