PLA2G2C [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G2C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G2C
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group IIC
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=391013|391013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5R387|Q5R387]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G2C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G2C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inactive phospholipase. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent phospholipase A2 activity|
|arachidonate transport|
|arachidonic acid secretion|
|icosanoid secretion|
|phospholipase A2 activity|
|icosanoid transport|
|fatty acid derivative transport|
|long-chain fatty acid transport|
|fatty acid transport|
|acid secretion|
|phospholipid binding|
|monocarboxylic acid transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|lipid localization|
|phospholipid metabolic process|
|organic anion transport|
|anion transport|
|calcium ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|secretion|
|lipid metabolic process|
|ion transport|
|organic substance catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|1.84|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17375
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G2C Expression in NALM6 Cells: 1.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>