PLA2G3 [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G3
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group III
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50487|50487]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ20|Q9NZ20]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611651|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269|PubMed:12522102, ECO:0000269|PubMed:20393563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sperm axoneme assembly|
|lipoxygenase pathway|
|calcium-dependent phospholipase A2 activity|
|mast cell activation involved in immune response|
|mast cell degranulation|
|acrosome assembly|
|phosphatidylglycerol acyl-chain remodeling|
|mast cell mediated immunity|
|mast cell granule|
|mast cell activation|
|arachidonic acid secretion|
|arachidonate transport|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|icosanoid secretion|
|phosphatidylglycerol metabolic process|
|icosanoid transport|
|fatty acid derivative transport|
|secretory granule organization|
|lysosome localization|
|long-chain fatty acid transport|
|axoneme assembly|
|flagellated sperm motility|
|sperm motility|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|microtubule bundle formation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|cellular component assembly involved in morphogenesis|
|icosanoid metabolic process|
|monocarboxylic acid transport|
|centriole|
|spermatid development|
|spermatid differentiation|
|fatty acid derivative metabolic process|
|ammonium ion metabolic process|
|germ cell development|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|lipid catabolic process|
|vesicle organization|
|glycerophospholipid metabolic process|
|lipid localization|
|fatty acid metabolic process|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|establishment of organelle localization|
|cilium organization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|organic anion transport|
|microtubule cytoskeleton organization|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|spermatogenesis|
|male gamete generation|
|organelle localization|
|anion transport|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|regulated exocytosis|
|organelle assembly|
|leukocyte mediated immunity|
|exocytosis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|lipid metabolic process|
|locomotion|
|ion transport|
|reproductive process|
|reproduction|
|intracellular transport|
|movement of cell or subcellular component|
|extracellular space|
|cell development|
|small molecule metabolic process|
|organic substance catabolic process|
|establishment of localization in cell|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G3 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>