PLA2G5 [The Human Chemical-Genetic Interaction Map Project]

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======= PLA2G5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLA2G5
  * **<color #00a2e8>Official Name</color>**: phospholipase A2 group V
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5322|5322]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P39877|P39877]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLA2G5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLA2G5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601192|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Phospholip A2 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|platelet activating factor biosynthetic process|
|platelet activating factor metabolic process|
|calcium-dependent phospholipase A2 activity|
|phosphatidylinositol acyl-chain remodeling|
|phosphatidylglycerol acyl-chain remodeling|
|leukotriene biosynthetic process|
|phosphatidylserine acyl-chain remodeling|
|arachidonic acid secretion|
|arachidonate transport|
|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|
|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|
|phosphatidylethanolamine acyl-chain remodeling|
|icosanoid secretion|
|phosphatidylcholine acyl-chain remodeling|
|phospholipase A2 activity|
|phosphatidylglycerol metabolic process|
|leukotriene metabolic process|
|fatty acid derivative transport|
|phosphatidylserine metabolic process|
|icosanoid transport|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|icosanoid biosynthetic process|
|long-chain fatty acid transport|
|positive regulation of phospholipase activity|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|fatty acid transport|
|phosphatidylcholine metabolic process|
|acid secretion|
|fatty acid derivative biosynthetic process|
|regulation of lipase activity|
|response to cAMP|
|phospholipid binding|
|icosanoid metabolic process|
|response to organophosphorus|
|monocarboxylic acid transport|
|response to purine-containing compound|
|fatty acid derivative metabolic process|
|phosphatidylinositol metabolic process|
|heparin binding|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|glycerophospholipid biosynthetic process|
|positive regulation of ERK1 and ERK2 cascade|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|organic acid transport|
|carboxylic acid transport|
|regulation of ERK1 and ERK2 cascade|
|lipid transport|
|lipid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|glycerophospholipid metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|drug metabolic process|
|organophosphate biosynthetic process|
|positive regulation of MAPK cascade|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|perinuclear region of cytoplasm|
|calcium ion binding|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|Golgi apparatus|
|response to organonitrogen compound|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|response to cytokine|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|lipid metabolic process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|ion transport|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLA2G5 Expression in NALM6 Cells: -3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>