PLAU [The Human Chemical-Genetic Interaction Map Project]

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======= PLAU =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLAU
  * **<color #00a2e8>Official Name</color>**: plasminogen activator, urokinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5328|5328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P00749|P00749]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLAU&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLAU|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kringle|
|Trypsin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of smooth muscle cell-matrix adhesion|
|smooth muscle cell migration|
|plasminogen activation|
|fibrinolysis|
|muscle cell migration|
|zymogen activation|
|regulation of cell adhesion mediated by integrin|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|regulation of smooth muscle cell migration|
|negative regulation of wound healing|
|tertiary granule membrane|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|specific granule membrane|
|regulation of cell-matrix adhesion|
|regulation of wound healing|
|protein processing|
|serine-type endopeptidase activity|
|regulation of response to wounding|
|regulation of signaling receptor activity|
|regulation of cell-substrate adhesion|
|protein maturation|
|blood coagulation|
|coagulation|
|hemostasis|
|response to hypoxia|
|response to decreased oxygen levels|
|negative regulation of response to external stimulus|
|response to oxygen levels|
|focal adhesion|
|wound healing|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|response to wounding|
|myeloid leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell adhesion|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|leukocyte activation|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|regulation of response to external stimulus|
|secretion|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|proteolysis|
|locomotion|
|regulation of response to stress|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12256
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLAU Expression in NALM6 Cells: 1.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>