PLD1 [The Human Chemical-Genetic Interaction Map Project]

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======= PLD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLD1
  * **<color #00a2e8>Official Name</color>**: phospholipase D1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5337|5337]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13393|Q13393]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|PX|
|PLDc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acylphosphatidylethanolamine-specific phospholipase D activity|
|regulation of microvillus assembly|
|phospholipase D activity|
|cholinergic synapse|
|regulation of microvillus organization|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|endocytic vesicle|
|tertiary granule membrane|
|inositol lipid-mediated signaling|
|phosphatidylinositol binding|
|specific granule membrane|
|regulation of synaptic vesicle cycle|
|late endosome membrane|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|Ras protein signal transduction|
|endosome|
|lipid catabolic process|
|lysosomal membrane|
|glycerophospholipid metabolic process|
|apical plasma membrane|
|small GTPase mediated signal transduction|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulated exocytosis|
|regulation of cell projection organization|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|regulation of cellular localization|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|Golgi apparatus|
|secretion by cell|
|export from cell|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|secretion|
|lipid metabolic process|
|locomotion|
|movement of cell or subcellular component|
|intracellular signal transduction|
|organic substance catabolic process|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.07|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.99|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.7|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLD1 Expression in NALM6 Cells: 1.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>