PLEKHA8 [The Human Chemical-Genetic Interaction Map Project]

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======= PLEKHA8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLEKHA8
  * **<color #00a2e8>Official Name</color>**: pleckstrin homology domain containing A8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84725|84725]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JA3|Q96JA3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLEKHA8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLEKHA8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608639|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. {ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:16103222, ECO:0000269|PubMed:17687330}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GLTP|
|PH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycolipid transfer activity|
|glycolipid binding|
|ceramide binding|
|ER to Golgi ceramide transport|
|glycolipid transport|
|ceramide 1-phosphate binding|
|intermembrane lipid transfer|
|ceramide 1-phosphate transfer activity|
|ceramide 1-phosphate transport|
|ceramide transport|
|phosphatidylinositol-4-phosphate binding|
|intracellular lipid transport|
|carbohydrate derivative transport|
|phospholipid transport|
|phosphatidylinositol biosynthetic process|
|organophosphate ester transport|
|lipid binding|
|phosphatidylinositol metabolic process|
|trans-Golgi network|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|lipid transport|
|glycerophospholipid metabolic process|
|lipid localization|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|organic anion transport|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|anion transport|
|Golgi membrane|
|membrane organization|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|Golgi apparatus|
|lipid metabolic process|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.73|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.83|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.54|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|3.29|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.54|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLEKHA8 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>