PLXNA2 [The Human Chemical-Genetic Interaction Map Project]

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======= PLXNA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PLXNA2
  * **<color #00a2e8>Official Name</color>**: plexin A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5362|5362]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75051|O75051]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PLXNA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PLXNA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601054|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250, ECO:0000269|PubMed:10520995}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIG|
|Plexin cytopl|
|Sema|
|PSI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cerebellar granule cell precursor tangential migration|
|hindbrain tangential cell migration|
|limb bud formation|
|semaphorin receptor complex|
|semaphorin-plexin signaling pathway involved in axon guidance|
|semaphorin receptor activity|
|semaphorin-plexin signaling pathway involved in neuron projection guidance|
|cell migration in hindbrain|
|pharyngeal system development|
|centrosome localization|
|microtubule organizing center localization|
|semaphorin-plexin signaling pathway|
|somitogenesis|
|somite development|
|positive regulation of axonogenesis|
|segmentation|
|limb morphogenesis|
|appendage morphogenesis|
|hindbrain development|
|regulation of cell shape|
|positive regulation of cell morphogenesis involved in differentiation|
|neural tube development|
|appendage development|
|limb development|
|regulation of axonogenesis|
|anterior/posterior pattern specification|
|axon guidance|
|neuron projection guidance|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|regionalization|
|positive regulation of neuron differentiation|
|axonogenesis|
|positive regulation of cell projection organization|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|pattern specification process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|localization of cell|
|cell motility|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7057
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PLXNA2 Expression in NALM6 Cells: -1.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>