PMPCB [The Human Chemical-Genetic Interaction Map Project]

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======= PMPCB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PMPCB
  * **<color #00a2e8>Official Name</color>**: peptidase, mitochondrial processing subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9512|9512]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75439|O75439]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PMPCB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PMPCB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603131|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves presequences (transit peptides) from mitochondrial protein precursors. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial processing peptidase complex|
|protein processing involved in protein targeting to mitochondrion|
|mitochondrial protein processing|
|mitochondrial calcium ion transmembrane transport|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|endopeptidase activity|
|protein localization to mitochondrion|
|metalloendopeptidase activity|
|protein processing|
|calcium ion transmembrane transport|
|mitochondrial transport|
|protein maturation|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|protein localization to organelle|
|cation transport|
|ion transmembrane transport|
|intracellular protein transport|
|mitochondrion|
|proteolysis|
|transmembrane transport|
|ion transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.76|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.7|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.75|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.77|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.78|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.84|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.91|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.95|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.15|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.17|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.19|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.47|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|3.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.745|
|[[:human genes:m:mars|MARS]]|0.473|
|[[:human genes:n:nsmce1|NSMCE1]]|0.44|
|[[:human genes:t:tbcd|TBCD]]|0.434|
|[[:human genes:g:gtf3a|GTF3A]]|0.427|
|[[:human genes:d:dhdds|DHDDS]]|0.414|
|[[:human genes:n:nae1|NAE1]]|0.414|
|[[:human genes:t:tsen2|TSEN2]]|0.413|
|[[:human genes:h:hspd1|HSPD1]]|0.412|
|[[:human genes:p:pisd|PISD]]|0.407|
|[[:human genes:t:tbca|TBCA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 718/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/26|
|breast|33/33|
|central nervous system|52/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PMPCB Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>