PNLIPRP2 [The Human Chemical-Genetic Interaction Map Project]

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======= PNLIPRP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PNLIPRP2
  * **<color #00a2e8>Official Name</color>**: pancreatic lipase related protein 2 (gene/pseudogene)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5408|5408]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54317|P54317]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PNLIPRP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PNLIPRP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis. {ECO:0000269|PubMed:18702514, ECO:0000269|PubMed:19824014, ECO:0000269|PubMed:20083229}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|galactolipase activity|
|1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity|
|intestinal lipid catabolic process|
|galactolipid catabolic process|
|acylglycerol lipase activity|
|galactolipid metabolic process|
|lipid digestion|
|glycolipid catabolic process|
|phospholipase activity|
|triglyceride lipase activity|
|lipase activity|
|membrane lipid catabolic process|
|phospholipid catabolic process|
|cellular defense response|
|triglyceride metabolic process|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|digestion|
|organophosphate catabolic process|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|lipid catabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|response to bacterium|
|calcium ion binding|
|organophosphate metabolic process|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|organic substance catabolic process|
|cellular catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15739
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PNLIPRP2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>