POLA1 [The Human Chemical-Genetic Interaction Map Project]

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======= POLA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLA1
  * **<color #00a2e8>Official Name</color>**: DNA polymerase alpha 1, catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5422|5422]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P09884|P09884]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/312040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids, which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227). {ECO:0000269|PubMed:27019227, ECO:0000269|PubMed:9518481}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol B exo1|
|DNA pol B|
|zf-DNA Pol|
|DNA pol alpha N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyrimidine nucleotide binding|
|purine nucleotide binding|
|DNA synthesis involved in UV-damage excision repair|
|leading strand elongation|
|lagging strand elongation|
|cell cycle DNA replication initiation|
|mitotic DNA replication initiation|
|nuclear cell cycle DNA replication initiation|
|nucleoside binding|
|DNA replication, synthesis of RNA primer|
|alpha DNA polymerase:primase complex|
|mitotic DNA replication|
|UV-damage excision repair|
|DNA strand elongation involved in DNA replication|
|DNA strand elongation|
|DNA replication origin binding|
|telomere maintenance via semi-conservative replication|
|regulation of transcription involved in G1/S transition of mitotic cell cycle|
|DNA-directed DNA polymerase activity|
|DNA replication initiation|
|4 iron, 4 sulfur cluster binding|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA synthesis involved in DNA repair|
|double-strand break repair via nonhomologous end joining|
|nucleotide binding|
|non-recombinational repair|
|cellular response to UV|
|telomere maintenance|
|telomere organization|
|single-stranded DNA binding|
|DNA biosynthetic process|
|nuclear matrix|
|nucleotide-excision repair|
|cellular response to light stimulus|
|chromatin|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|response to UV|
|cellular response to radiation|
|nuclear envelope|
|double-strand break repair|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|anatomical structure homeostasis|
|chromatin binding|
|response to radiation|
|protein kinase binding|
|DNA repair|
|cell population proliferation|
|mitotic cell cycle process|
|RNA biosynthetic process|
|mitotic cell cycle|
|viral process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|nucleolus|
|cellular homeostasis|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-3.81|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-3.74|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.85|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.67|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.63|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.38|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.34|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.29|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.28|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.27|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.25|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.1|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.04|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.03|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.99|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.92|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.91|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-1.87|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.7|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.71|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.72|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.73|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.74|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.74|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.77|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.78|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.78|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.79|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.81|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.83|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.83|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.83|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.86|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.87|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.87|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.9|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.91|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.94|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.97|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.98|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|2.04|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.05|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.05|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|2.06|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.08|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.14|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.18|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.21|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.23|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|2.23|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|2.31|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.33|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|2.59|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|2.71|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.89|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|3|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|3.05|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|3.22|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|3.27|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|3.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.541|
|[[:human genes:n:npipb5|NPIPB5]]|0.529|
|[[:human genes:c:chd4|CHD4]]|0.528|
|[[:human genes:g:golga8j|GOLGA8J]]|0.522|
|[[:human genes:r:rrp7a|RRP7A]]|0.512|
|[[:human genes:u:upf1|UPF1]]|0.51|
|[[:human genes:r:rbbp5|RBBP5]]|0.51|
|[[:human genes:t:tceb3c|TCEB3C]]|0.507|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.506|
|[[:human genes:r:rpl35|RPL35]]|0.506|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.505|
|[[:human genes:f:fam25b|FAM25B]]|0.503|
|[[:human genes:c:ccdc116|CCDC116]]|0.499|
|[[:human genes:e:exosc5|EXOSC5]]|0.499|
|[[:human genes:e:exosc6|EXOSC6]]|0.498|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.497|
|[[:human genes:c:ccna2|CCNA2]]|0.497|
|[[:human genes:c:cbwd5|CBWD5]]|0.494|
|[[:human genes:a:arcn1|ARCN1]]|0.494|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.494|
|[[:human genes:c:cbwd3|CBWD3]]|0.493|
|[[:human genes:n:nup160|NUP160]]|0.491|
|[[:human genes:x:xab2|XAB2]]|0.488|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.488|
|[[:human genes:c:cbwd6|CBWD6]]|0.485|
|[[:human genes:v:vasn|VASN]]|0.485|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.482|
|[[:human genes:r:rps5|RPS5]]|0.482|
|[[:human genes:k:kif3c|KIF3C]]|0.481|
|[[:human genes:s:slc38a7|SLC38A7]]|0.481|
|[[:human genes:a:ankle2|ANKLE2]]|0.481|
|[[:human genes:r:rps2|RPS2]]|0.48|
|[[:human genes:r:rps12|RPS12]]|0.478|
|[[:human genes:s:supt6h|SUPT6H]]|0.476|
|[[:human genes:c:cgb2|CGB2]]|0.475|
|[[:human genes:s:slc6a17|SLC6A17]]|0.475|
|[[:human genes:d:ddx56|DDX56]]|0.474|
|[[:human genes:u:uqcrh|UQCRH]]|0.473|
|[[:human genes:d:ddtl|DDTL]]|0.472|
|[[:human genes:s:stil|STIL]]|0.471|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.467|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.467|
|[[:human genes:r:rad21|RAD21]]|0.466|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.465|
|[[:human genes:i:iscu|ISCU]]|0.465|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.464|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.462|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.462|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.462|
|[[:human genes:s:supt5h|SUPT5H]]|0.461|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.461|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.461|
|[[:human genes:n:nol10|NOL10]]|0.457|
|[[:human genes:p:pan3|PAN3]]|0.457|
|[[:human genes:l:lad1|LAD1]]|0.455|
|[[:human genes:p:paf1|PAF1]]|0.455|
|[[:human genes:n:nup205|NUP205]]|0.454|
|[[:human genes:r:rpl30|RPL30]]|0.454|
|[[:human genes:y:ythdc1|YTHDC1]]|0.454|
|[[:human genes:p:pan2|PAN2]]|0.453|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.453|
|[[:human genes:f:fam86b2|FAM86B2]]|0.453|
|[[:human genes:b:bysl|BYSL]]|0.453|
|[[:human genes:c:copg1|COPG1]]|0.453|
|[[:human genes:p:pwp2|PWP2]]|0.452|
|[[:human genes:p:psma6|PSMA6]]|0.451|
|[[:human genes:p:psmb2|PSMB2]]|0.451|
|[[:human genes:k:kctd17|KCTD17]]|0.449|
|[[:human genes:p:psma7|PSMA7]]|0.449|
|[[:human genes:n:nup133|NUP133]]|0.449|
|[[:human genes:h:hivep3|HIVEP3]]|0.448|
|[[:human genes:f:fam160a1|FAM160A1]]|0.448|
|[[:human genes:w:wdr75|WDR75]]|0.448|
|[[:human genes:c:cope|COPE]]|0.447|
|[[:human genes:c:chchd3|CHCHD3]]|0.446|
|[[:human genes:m:mt1e|MT1E]]|0.446|
|[[:human genes:n:nupl1|NUPL1]]|0.446|
|[[:human genes:n:nup98|NUP98]]|0.446|
|[[:human genes:p:prkcz|PRKCZ]]|0.445|
|[[:human genes:v:vps52|VPS52]]|0.444|
|[[:human genes:r:rps20|RPS20]]|0.443|
|[[:human genes:g:golga8o|GOLGA8O]]|0.442|
|[[:human genes:c:copa|COPA]]|0.442|
|[[:human genes:c:c14orf93|C14orf93]]|0.442|
|[[:human genes:m:myt1l|MYT1L]]|0.442|
|[[:human genes:n:nfatc4|NFATC4]]|0.438|
|[[:human genes:g:golga8k|GOLGA8K]]|0.437|
|[[:human genes:t:tspy8|TSPY8]]|0.436|
|[[:human genes:h:hinfp|HINFP]]|0.436|
|[[:human genes:p:polr2d|POLR2D]]|0.435|
|[[:human genes:s:sec13|SEC13]]|0.435|
|[[:human genes:r:rpl6|RPL6]]|0.434|
|[[:human genes:z:znf830|ZNF830]]|0.434|
|[[:human genes:m:myb|MYB]]|0.434|
|[[:human genes:r:rnf121|RNF121]]|0.433|
|[[:human genes:n:napa|NAPA]]|0.433|
|[[:human genes:c:col2a1|COL2A1]]|0.432|
|[[:human genes:p:psmd11|PSMD11]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.432|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.432|
|[[:human genes:e:exosc9|EXOSC9]]|0.43|
|[[:human genes:c:cebpz|CEBPZ]]|0.43|
|[[:human genes:r:rps9|RPS9]]|0.429|
|[[:human genes:o:ogfr|OGFR]]|0.429|
|[[:human genes:r:rps19|RPS19]]|0.429|
|[[:human genes:c:copb2|COPB2]]|0.429|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.428|
|[[:human genes:c:cdc45|CDC45]]|0.428|
|[[:human genes:c:cwc22|CWC22]]|0.426|
|[[:human genes:p:psap|PSAP]]|0.426|
|[[:human genes:r:rps28|RPS28]]|0.426|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.425|
|[[:human genes:p:psmb1|PSMB1]]|0.425|
|[[:human genes:e:eif4a3|EIF4A3]]|0.425|
|[[:human genes:t:timeless|TIMELESS]]|0.425|
|[[:human genes:m:myo18a|MYO18A]]|0.425|
|[[:human genes:l:lrr1|LRR1]]|0.425|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.425|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.425|
|[[:human genes:p:pole|POLE]]|0.424|
|[[:human genes:s:snip1|SNIP1]]|0.423|
|[[:human genes:t:trim52|TRIM52]]|0.423|
|[[:human genes:k:krt78|KRT78]]|0.423|
|[[:human genes:d:dhfr|DHFR]]|0.421|
|[[:human genes:n:nup155|NUP155]]|0.421|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.421|
|[[:human genes:v:vps51|VPS51]]|0.421|
|[[:human genes:d:disp2|DISP2]]|0.421|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.42|
|[[:human genes:o:orc1|ORC1]]|0.42|
|[[:human genes:r:rad51|RAD51]]|0.419|
|[[:human genes:p:pola2|POLA2]]|0.419|
|[[:human genes:p:plk4|PLK4]]|0.419|
|[[:human genes:c:cacna1a|CACNA1A]]|0.418|
|[[:human genes:a:aamp|AAMP]]|0.417|
|[[:human genes:o:or10g3|OR10G3]]|0.417|
|[[:human genes:g:golga8r|GOLGA8R]]|0.416|
|[[:human genes:s:sf3a1|SF3A1]]|0.416|
|[[:human genes:c:chaf1a|CHAF1A]]|0.415|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.415|
|[[:human genes:m:med15|MED15]]|0.415|
|[[:human genes:m:med17|MED17]]|0.414|
|[[:human genes:s:syt15|SYT15]]|0.414|
|[[:human genes:r:rps7|RPS7]]|0.412|
|[[:human genes:u:utp3|UTP3]]|0.412|
|[[:human genes:p:psmc2|PSMC2]]|0.412|
|[[:human genes:n:ngdn|NGDN]]|0.412|
|[[:human genes:s:snrpa1|SNRPA1]]|0.411|
|[[:human genes:t:tfip11|TFIP11]]|0.41|
|[[:human genes:r:riok2|RIOK2]]|0.41|
|[[:human genes:r:rps10|RPS10]]|0.409|
|[[:human genes:t:tspy1|TSPY1]]|0.409|
|[[:human genes:p:psmd14|PSMD14]]|0.408|
|[[:human genes:r:rilpl2|RILPL2]]|0.408|
|[[:human genes:p:polr2j3|POLR2J3]]|0.408|
|[[:human genes:r:rnpc3|RNPC3]]|0.408|
|[[:human genes:p:psmb3|PSMB3]]|0.408|
|[[:human genes:a:acsf2|ACSF2]]|0.408|
|[[:human genes:p:psmc6|PSMC6]]|0.407|
|[[:human genes:p:prim1|PRIM1]]|0.407|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.406|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.406|
|[[:human genes:s:sult1a4|SULT1A4]]|0.405|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.405|
|[[:human genes:t:traip|TRAIP]]|0.405|
|[[:human genes:s:sult1a3|SULT1A3]]|0.405|
|[[:human genes:a:aqr|AQR]]|0.405|
|[[:human genes:p:psmd2|PSMD2]]|0.403|
|[[:human genes:f:fcn2|FCN2]]|0.402|
|[[:human genes:n:npipb8|NPIPB8]]|0.402|
|[[:human genes:e:eftud2|EFTUD2]]|0.402|
|[[:human genes:c:cdrt15|CDRT15]]|0.401|
|[[:human genes:p:psmd8|PSMD8]]|0.4|
|[[:human genes:s:sys1|SYS1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 293/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|13/26|
|bone|11/26|
|breast|19/30|
|central nervous system|15/49|
|cervix|1/4|
|colorectal|7/17|
|esophagus|5/11|
|fibroblast|0/1|
|gastric|5/14|
|kidney|3/18|
|liver|6/19|
|lung|30/72|
|lymphocyte|4/16|
|ovary|15/25|
|pancreas|10/22|
|peripheral nervous system|9/15|
|plasma cell|6/12|
|prostate|1/1|
|skin|7/20|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|9/22|
|urinary tract|7/28|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 613
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLA1 Expression in NALM6 Cells: 6.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>