POLA2 [The Human Chemical-Genetic Interaction Map Project]

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======= POLA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLA2
  * **<color #00a2e8>Official Name</color>**: DNA polymerase alpha 2, accessory subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23649|23649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14181|Q14181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620063|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol E B|
|Pol alpha B N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha DNA polymerase:primase complex|
|telomere maintenance via semi-conservative replication|
|DNA-directed DNA polymerase activity|
|DNA replication initiation|
|nuclear DNA replication|
|cell cycle DNA replication|
|telomere maintenance|
|telomere organization|
|DNA biosynthetic process|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|anatomical structure homeostasis|
|protein heterodimerization activity|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|molecular function|
|cellular homeostasis|
|cell cycle process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|DNA binding|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.36|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.29|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.22|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.21|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.11|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.94|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.91|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.8|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.73|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.71|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.75|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.77|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.78|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.78|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.79|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.81|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.82|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.82|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|1.82|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.83|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.86|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.86|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.89|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.9|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.92|
|[[:results:exp169|BH1 1μM R04 exp169]]|1.94|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.95|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.99|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.99|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.03|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.06|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.11|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.25|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.51|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.53|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.55|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|2.66|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:orc6|ORC6]]|0.546|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.543|
|[[:human genes:d:dido1|DIDO1]]|0.532|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.526|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.521|
|[[:human genes:v:vasn|VASN]]|0.516|
|[[:human genes:p:psmb4|PSMB4]]|0.512|
|[[:human genes:c:chd4|CHD4]]|0.511|
|[[:human genes:s:supt6h|SUPT6H]]|0.509|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.507|
|[[:human genes:t:traip|TRAIP]]|0.507|
|[[:human genes:k:krt78|KRT78]]|0.501|
|[[:human genes:r:rpl35|RPL35]]|0.501|
|[[:human genes:t:tceb3c|TCEB3C]]|0.499|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.498|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.498|
|[[:human genes:p:psma6|PSMA6]]|0.497|
|[[:human genes:s:smg1|SMG1]]|0.497|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.492|
|[[:human genes:c:cdca3|CDCA3]]|0.491|
|[[:human genes:h:hap1|HAP1]]|0.491|
|[[:human genes:r:rbbp5|RBBP5]]|0.491|
|[[:human genes:p:prim1|PRIM1]]|0.49|
|[[:human genes:c:cdc73|CDC73]]|0.49|
|[[:human genes:r:rps2|RPS2]]|0.49|
|[[:human genes:p:psmd11|PSMD11]]|0.489|
|[[:human genes:c:c14orf93|C14orf93]]|0.486|
|[[:human genes:r:rps3a|RPS3A]]|0.485|
|[[:human genes:r:rpl7a|RPL7A]]|0.485|
|[[:human genes:r:rad21|RAD21]]|0.485|
|[[:human genes:w:wdr43|WDR43]]|0.484|
|[[:human genes:g:golga8o|GOLGA8O]]|0.483|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.48|
|[[:human genes:p:pcf11|PCF11]]|0.479|
|[[:human genes:u:upf1|UPF1]]|0.479|
|[[:human genes:t:ticrr|TICRR]]|0.479|
|[[:human genes:r:rpl6|RPL6]]|0.478|
|[[:human genes:z:zfand5|ZFAND5]]|0.477|
|[[:human genes:n:nbpf10|NBPF10]]|0.476|
|[[:human genes:s:slc4a1|SLC4A1]]|0.473|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.471|
|[[:human genes:s:ssh2|SSH2]]|0.47|
|[[:human genes:r:rrp15|RRP15]]|0.467|
|[[:human genes:c:cbwd3|CBWD3]]|0.467|
|[[:human genes:s:sf3a1|SF3A1]]|0.467|
|[[:human genes:s:smg7|SMG7]]|0.465|
|[[:human genes:o:orc1|ORC1]]|0.465|
|[[:human genes:p:psmb3|PSMB3]]|0.462|
|[[:human genes:c:cdc45|CDC45]]|0.462|
|[[:human genes:p:polr1a|POLR1A]]|0.461|
|[[:human genes:t:twistnb|TWISTNB]]|0.46|
|[[:human genes:p:polr2j3|POLR2J3]]|0.46|
|[[:human genes:r:rrn3|RRN3]]|0.459|
|[[:human genes:d:ddx56|DDX56]]|0.458|
|[[:human genes:d:ddtl|DDTL]]|0.458|
|[[:human genes:c:col2a1|COL2A1]]|0.458|
|[[:human genes:n:npipb5|NPIPB5]]|0.456|
|[[:human genes:t:tspy1|TSPY1]]|0.456|
|[[:human genes:n:narfl|NARFL]]|0.454|
|[[:human genes:m:myo1h|MYO1H]]|0.454|
|[[:human genes:r:rps5|RPS5]]|0.452|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.452|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.452|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.451|
|[[:human genes:g:gga3|GGA3]]|0.451|
|[[:human genes:c:cbwd5|CBWD5]]|0.451|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.451|
|[[:human genes:k:kctd17|KCTD17]]|0.45|
|[[:human genes:a:aamp|AAMP]]|0.45|
|[[:human genes:w:wdr75|WDR75]]|0.448|
|[[:human genes:r:rpl14|RPL14]]|0.448|
|[[:human genes:r:rpa2|RPA2]]|0.446|
|[[:human genes:c:ccdc116|CCDC116]]|0.446|
|[[:human genes:r:rad51|RAD51]]|0.446|
|[[:human genes:d:dtl|DTL]]|0.445|
|[[:human genes:p:pan3|PAN3]]|0.445|
|[[:human genes:p:paf1|PAF1]]|0.444|
|[[:human genes:p:psmd1|PSMD1]]|0.444|
|[[:human genes:c:cwc22|CWC22]]|0.444|
|[[:human genes:m:mt1e|MT1E]]|0.444|
|[[:human genes:c:ctage4|CTAGE4]]|0.442|
|[[:human genes:e:exosc6|EXOSC6]]|0.442|
|[[:human genes:z:znf655|ZNF655]]|0.44|
|[[:human genes:a:ankle2|ANKLE2]]|0.439|
|[[:human genes:s:slc6a17|SLC6A17]]|0.439|
|[[:human genes:i:igfn1|IGFN1]]|0.438|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.437|
|[[:human genes:p:psap|PSAP]]|0.437|
|[[:human genes:c:ctr9|CTR9]]|0.436|
|[[:human genes:r:rps9|RPS9]]|0.435|
|[[:human genes:c:cbwd6|CBWD6]]|0.435|
|[[:human genes:p:prpf8|PRPF8]]|0.435|
|[[:human genes:z:znf106|ZNF106]]|0.434|
|[[:human genes:i:ik|IK]]|0.433|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.433|
|[[:human genes:s:snrpa1|SNRPA1]]|0.432|
|[[:human genes:p:ppfia4|PPFIA4]]|0.432|
|[[:human genes:c:cdc6|CDC6]]|0.432|
|[[:human genes:m:myb|MYB]]|0.431|
|[[:human genes:n:nupl1|NUPL1]]|0.431|
|[[:human genes:c:cope|COPE]]|0.429|
|[[:human genes:s:snrnp70|SNRNP70]]|0.429|
|[[:human genes:n:nip7|NIP7]]|0.428|
|[[:human genes:p:psma7|PSMA7]]|0.428|
|[[:human genes:p:psmb2|PSMB2]]|0.428|
|[[:human genes:p:polr2j|POLR2J]]|0.427|
|[[:human genes:r:rps12|RPS12]]|0.427|
|[[:human genes:r:rps7|RPS7]]|0.426|
|[[:human genes:t:tfip11|TFIP11]]|0.426|
|[[:human genes:f:fam160a1|FAM160A1]]|0.425|
|[[:human genes:a:akirin2|AKIRIN2]]|0.424|
|[[:human genes:r:rpl9|RPL9]]|0.424|
|[[:human genes:p:pan2|PAN2]]|0.423|
|[[:human genes:s:ssrp1|SSRP1]]|0.423|
|[[:human genes:s:stil|STIL]]|0.422|
|[[:human genes:n:nol10|NOL10]]|0.422|
|[[:human genes:p:pola1|POLA1]]|0.419|
|[[:human genes:r:rbm39|RBM39]]|0.419|
|[[:human genes:p:pwp2|PWP2]]|0.419|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.418|
|[[:human genes:u:urb2|URB2]]|0.418|
|[[:human genes:n:ncapg|NCAPG]]|0.417|
|[[:human genes:i:iscu|ISCU]]|0.417|
|[[:human genes:p:psmc1|PSMC1]]|0.417|
|[[:human genes:a:acsf2|ACSF2]]|0.417|
|[[:human genes:n:nup160|NUP160]]|0.416|
|[[:human genes:n:nhp2l1|NHP2L1]]|0.416|
|[[:human genes:r:rnf4|RNF4]]|0.415|
|[[:human genes:a:ahctf1|AHCTF1]]|0.415|
|[[:human genes:c:ckap5|CKAP5]]|0.414|
|[[:human genes:c:chchd3|CHCHD3]]|0.414|
|[[:human genes:r:rps3|RPS3]]|0.414|
|[[:human genes:p:psmd3|PSMD3]]|0.414|
|[[:human genes:s:sf3a3|SF3A3]]|0.412|
|[[:human genes:c:cacna1a|CACNA1A]]|0.412|
|[[:human genes:e:elmod3|ELMOD3]]|0.412|
|[[:human genes:b:brd2|BRD2]]|0.412|
|[[:human genes:d:ddx47|DDX47]]|0.411|
|[[:human genes:i:ints6|INTS6]]|0.411|
|[[:human genes:n:nipbl|NIPBL]]|0.411|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.411|
|[[:human genes:p:psmc2|PSMC2]]|0.41|
|[[:human genes:r:rnf113a|RNF113A]]|0.41|
|[[:human genes:u:ubl5|UBL5]]|0.409|
|[[:human genes:p:ppie|PPIE]]|0.409|
|[[:human genes:c:cactin|CACTIN]]|0.408|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.408|
|[[:human genes:r:rilpl2|RILPL2]]|0.408|
|[[:human genes:c:copa|COPA]]|0.407|
|[[:human genes:o:ogfr|OGFR]]|0.407|
|[[:human genes:s:snrnp200|SNRNP200]]|0.407|
|[[:human genes:t:ttyh1|TTYH1]]|0.407|
|[[:human genes:p:psmd14|PSMD14]]|0.407|
|[[:human genes:r:rps28|RPS28]]|0.406|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.405|
|[[:human genes:b:bysl|BYSL]]|0.405|
|[[:human genes:n:nup133|NUP133]]|0.404|
|[[:human genes:s:scaf1|SCAF1]]|0.404|
|[[:human genes:r:rnf121|RNF121]]|0.403|
|[[:human genes:u:utp20|UTP20]]|0.403|
|[[:human genes:n:nup62|NUP62]]|0.402|
|[[:human genes:s:sfpq|SFPQ]]|0.402|
|[[:human genes:a:aqr|AQR]]|0.402|
|[[:human genes:r:ranbp2|RANBP2]]|0.402|
|[[:human genes:n:nup43|NUP43]]|0.402|
|[[:human genes:p:psmc6|PSMC6]]|0.402|
|[[:human genes:k:krt2|KRT2]]|0.401|
|[[:human genes:n:nup153|NUP153]]|0.401|
|[[:human genes:c:casc3|CASC3]]|0.401|
|[[:human genes:c:copb2|COPB2]]|0.401|
|[[:human genes:m:med17|MED17]]|0.4|
|[[:human genes:p:psmb1|PSMB1]]|0.4|
|[[:human genes:p:pole|POLE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 410/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|17/28|
|blood|13/28|
|bone|16/26|
|breast|20/33|
|central nervous system|32/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|11/21|
|liver|16/20|
|lung|40/75|
|lymphocyte|9/16|
|ovary|16/26|
|pancreas|12/24|
|peripheral nervous system|11/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|3/22|
|urinary tract|14/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLA2 Expression in NALM6 Cells: 6.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>