POLG [The Human Chemical-Genetic Interaction Map Project]

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======= POLG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLG
  * **<color #00a2e8>Official Name</color>**: DNA polymerase gamma, catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5428|5428]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54098|P54098]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/174763|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DNA pol A|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma DNA polymerase complex|
|base-excision repair, gap-filling|
|mitochondrial DNA replication|
|3-5 exonuclease activity|
|response to hyperoxia|
|DNA-directed DNA polymerase activity|
|response to increased oxygen levels|
|base-excision repair|
|mitochondrial nucleoid|
|terminal bouton|
|response to gamma radiation|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|protease binding|
|DNA biosynthetic process|
|DNA-dependent DNA replication|
|response to glucose|
|response to hexose|
|response to ionizing radiation|
|response to monosaccharide|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|DNA replication|
|aging|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|response to oxygen levels|
|chromatin binding|
|response to radiation|
|DNA repair|
|protein-containing complex|
|cellular chemical homeostasis|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular homeostasis|
|cellular response to oxygen-containing compound|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|DNA binding|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-2.4|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.04|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|-1.89|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.81|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.8|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.79|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.78|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.71|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.7|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.71|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.71|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.73|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.9|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.01|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.04|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.05|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.1|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.21|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.35|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.48|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.59|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.63|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.614|
|[[:human genes:y:yars2|YARS2]]|0.597|
|[[:human genes:p:polg2|POLG2]]|0.589|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.585|
|[[:human genes:n:ndufb11|NDUFB11]]|0.58|
|[[:human genes:t:tars2|TARS2]]|0.58|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.579|
|[[:human genes:p:pars2|PARS2]]|0.57|
|[[:human genes:g:gatc|GATC]]|0.569|
|[[:human genes:c:c12orf65|C12orf65]]|0.569|
|[[:human genes:c:coa3|COA3]]|0.559|
|[[:human genes:m:mrps34|MRPS34]]|0.556|
|[[:human genes:m:mrps5|MRPS5]]|0.555|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.555|
|[[:human genes:g:gfm1|GFM1]]|0.553|
|[[:human genes:n:ndufa3|NDUFA3]]|0.549|
|[[:human genes:q:qrsl1|QRSL1]]|0.547|
|[[:human genes:s:selrc1|SELRC1]]|0.544|
|[[:human genes:i:iba57|IBA57]]|0.542|
|[[:human genes:m:mrpl21|MRPL21]]|0.54|
|[[:human genes:e:ears2|EARS2]]|0.539|
|[[:human genes:f:ftsj2|FTSJ2]]|0.539|
|[[:human genes:w:wars2|WARS2]]|0.538|
|[[:human genes:m:mrps6|MRPS6]]|0.536|
|[[:human genes:r:rbfa|RBFA]]|0.536|
|[[:human genes:p:polrmt|POLRMT]]|0.535|
|[[:human genes:n:ndufa2|NDUFA2]]|0.534|
|[[:human genes:r:rars2|RARS2]]|0.534|
|[[:human genes:c:cox11|COX11]]|0.533|
|[[:human genes:l:lars2|LARS2]]|0.532|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.53|
|[[:human genes:r:rpusd4|RPUSD4]]|0.528|
|[[:human genes:d:dars2|DARS2]]|0.527|
|[[:human genes:n:ndufb9|NDUFB9]]|0.526|
|[[:human genes:m:mrps16|MRPS16]]|0.523|
|[[:human genes:t:tefm|TEFM]]|0.522|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.521|
|[[:human genes:m:mettl17|METTL17]]|0.521|
|[[:human genes:s:sco2|SCO2]]|0.517|
|[[:human genes:n:ndufb5|NDUFB5]]|0.515|
|[[:human genes:d:dap3|DAP3]]|0.513|
|[[:human genes:m:mrps21|MRPS21]]|0.51|
|[[:human genes:b:bcs1l|BCS1L]]|0.509|
|[[:human genes:m:mrps14|MRPS14]]|0.505|
|[[:human genes:p:pet112|PET112]]|0.503|
|[[:human genes:a:acad9|ACAD9]]|0.502|
|[[:human genes:m:mrpl47|MRPL47]]|0.501|
|[[:human genes:n:ndufa8|NDUFA8]]|0.501|
|[[:human genes:m:mrpl11|MRPL11]]|0.5|
|[[:human genes:m:mto1|MTO1]]|0.499|
|[[:human genes:m:mrps11|MRPS11]]|0.499|
|[[:human genes:d:dhrsx|DHRSX]]|0.498|
|[[:human genes:n:nubpl|NUBPL]]|0.498|
|[[:human genes:c:c10orf2|C10orf2]]|0.495|
|[[:human genes:f:fastkd5|FASTKD5]]|0.494|
|[[:human genes:c:c17orf89|C17orf89]]|0.493|
|[[:human genes:m:mrpl15|MRPL15]]|0.491|
|[[:human genes:n:ndufb6|NDUFB6]]|0.491|
|[[:human genes:m:mrps33|MRPS33]]|0.488|
|[[:human genes:p:pet117|PET117]]|0.487|
|[[:human genes:m:mrpl53|MRPL53]]|0.482|
|[[:human genes:p:pgm3|PGM3]]|0.48|
|[[:human genes:m:mrpl12|MRPL12]]|0.48|
|[[:human genes:m:mtg1|MTG1]]|0.479|
|[[:human genes:m:mrps17|MRPS17]]|0.478|
|[[:human genes:t:trmt61a|TRMT61A]]|0.477|
|[[:human genes:m:mipep|MIPEP]]|0.476|
|[[:human genes:n:ndufa10|NDUFA10]]|0.475|
|[[:human genes:m:mrpl23|MRPL23]]|0.475|
|[[:human genes:n:ndufs2|NDUFS2]]|0.474|
|[[:human genes:m:malsu1|MALSU1]]|0.474|
|[[:human genes:n:ndufa1|NDUFA1]]|0.474|
|[[:human genes:p:pmvk|PMVK]]|0.473|
|[[:human genes:g:gfm2|GFM2]]|0.47|
|[[:human genes:c:chchd4|CHCHD4]]|0.467|
|[[:human genes:t:tmem242|TMEM242]]|0.466|
|[[:human genes:m:mrp63|MRP63]]|0.465|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.463|
|[[:human genes:v:vars2|VARS2]]|0.463|
|[[:human genes:c:coq2|COQ2]]|0.46|
|[[:human genes:m:mars2|MARS2]]|0.458|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.458|
|[[:human genes:a:aars2|AARS2]]|0.457|
|[[:human genes:m:mrpl20|MRPL20]]|0.457|
|[[:human genes:t:tfb1m|TFB1M]]|0.456|
|[[:human genes:l:lsm10|LSM10]]|0.456|
|[[:human genes:g:grsf1|GRSF1]]|0.455|
|[[:human genes:m:mterfd2|MTERFD2]]|0.451|
|[[:human genes:w:wbscr16|WBSCR16]]|0.451|
|[[:human genes:m:mrps18a|MRPS18A]]|0.45|
|[[:human genes:c:coa6|COA6]]|0.45|
|[[:human genes:e:ecsit|ECSIT]]|0.449|
|[[:human genes:m:mrpl45|MRPL45]]|0.449|
|[[:human genes:t:tmem261|TMEM261]]|0.447|
|[[:human genes:a:atp5sl|ATP5SL]]|0.445|
|[[:human genes:m:mrps27|MRPS27]]|0.442|
|[[:human genes:m:mcat|MCAT]]|0.442|
|[[:human genes:p:pitrm1|PITRM1]]|0.441|
|[[:human genes:d:ddx28|DDX28]]|0.441|
|[[:human genes:t:tmem126b|TMEM126B]]|0.44|
|[[:human genes:s:ssbp1|SSBP1]]|0.439|
|[[:human genes:r:rpia|RPIA]]|0.438|
|[[:human genes:c:cox16|COX16]]|0.437|
|[[:human genes:m:mrps2|MRPS2]]|0.436|
|[[:human genes:a:alg8|ALG8]]|0.436|
|[[:human genes:c:cars2|CARS2]]|0.436|
|[[:human genes:f:fars2|FARS2]]|0.435|
|[[:human genes:t:tufm|TUFM]]|0.433|
|[[:human genes:c:cox15|COX15]]|0.432|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.432|
|[[:human genes:s:sars2|SARS2]]|0.432|
|[[:human genes:m:mrps24|MRPS24]]|0.432|
|[[:human genes:n:ndufb3|NDUFB3]]|0.432|
|[[:human genes:m:mtg2|MTG2]]|0.432|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.43|
|[[:human genes:n:ndufc2|NDUFC2]]|0.429|
|[[:human genes:m:mrps26|MRPS26]]|0.429|
|[[:human genes:c:cox5a|COX5A]]|0.425|
|[[:human genes:t:tomm20|TOMM20]]|0.422|
|[[:human genes:d:dnlz|DNLZ]]|0.422|
|[[:human genes:f:foxred1|FOXRED1]]|0.421|
|[[:human genes:r:rft1|RFT1]]|0.421|
|[[:human genes:f:fastkd1|FASTKD1]]|0.42|
|[[:human genes:n:ndufs7|NDUFS7]]|0.419|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.418|
|[[:human genes:a:alg6|ALG6]]|0.418|
|[[:human genes:m:mrpl3|MRPL3]]|0.417|
|[[:human genes:s:slc25a26|SLC25A26]]|0.416|
|[[:human genes:h:hars2|HARS2]]|0.414|
|[[:human genes:r:rpusd3|RPUSD3]]|0.413|
|[[:human genes:n:nsun4|NSUN4]]|0.411|
|[[:human genes:t:tpk1|TPK1]]|0.41|
|[[:human genes:p:pet100|PET100]]|0.409|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.408|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.407|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.406|
|[[:human genes:m:mrps22|MRPS22]]|0.405|
|[[:human genes:c:chchd1|CHCHD1]]|0.404|
|[[:human genes:p:pdss1|PDSS1]]|0.404|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.403|
|[[:human genes:m:mrps25|MRPS25]]|0.401|
|[[:human genes:n:ndufa11|NDUFA11]]|0.4|
|[[:human genes:f:fh|FH]]|0.4|
|[[:human genes:s:ssb|SSB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|3/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2409
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLG Expression in NALM6 Cells: 7.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>