POLR2D [The Human Chemical-Genetic Interaction Map Project]

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======= POLR2D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2D
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5433|5433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15514|O15514]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol Rpb4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|recruitment of 3-end processing factors to RNA polymerase II holoenzyme complex|
|mRNA export from nucleus in response to heat stress|
|RNA polymerase II, core complex|
|translation initiation factor binding|
|positive regulation of translational initiation|
|DNA-directed 5-3 RNA polymerase activity|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|positive regulation of viral transcription|
|single-stranded RNA binding|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nucleotide binding|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|snRNA transcription by RNA polymerase II|
|cellular response to heat|
|snRNA transcription|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|regulation of translational initiation|
|fibroblast growth factor receptor signaling pathway|
|mRNA 3-end processing|
|P-body|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|single-stranded DNA binding|
|positive regulation of viral process|
|cellular response to fibroblast growth factor stimulus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|response to heat|
|nucleotide-excision repair|
|response to fibroblast growth factor|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|positive regulation of translation|
|RNA export from nucleus|
|regulation of gene silencing|
|stem cell population maintenance|
|RNA 3-end processing|
|maintenance of cell number|
|protein export from nucleus|
|positive regulation of cellular amide metabolic process|
|mRNA transport|
|nuclear export|
|transcription initiation from RNA polymerase II promoter|
|response to temperature stimulus|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|nuclear-transcribed mRNA catabolic process|
|regulation of viral process|
|RNA localization|
|mRNA catabolic process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of translation|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|nuclear speck|
|regulation of cellular amide metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|intracellular protein transport|
|macromolecule catabolic process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.2|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.84|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.83|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.81|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.73|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.73|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.82|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.86|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.89|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.92|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.93|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.16|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.571|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.543|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.538|
|[[:human genes:c:cbwd3|CBWD3]]|0.522|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.519|
|[[:human genes:p:polr2j3|POLR2J3]]|0.517|
|[[:human genes:p:psmd2|PSMD2]]|0.512|
|[[:human genes:m:myb|MYB]]|0.509|
|[[:human genes:c:cbwd5|CBWD5]]|0.508|
|[[:human genes:r:rnpc3|RNPC3]]|0.508|
|[[:human genes:p:psma6|PSMA6]]|0.504|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.503|
|[[:human genes:c:ccna2|CCNA2]]|0.5|
|[[:human genes:e:exosc9|EXOSC9]]|0.497|
|[[:human genes:r:rrp7a|RRP7A]]|0.49|
|[[:human genes:p:psmb4|PSMB4]]|0.489|
|[[:human genes:t:tceb3c|TCEB3C]]|0.487|
|[[:human genes:s:supt5h|SUPT5H]]|0.487|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.486|
|[[:human genes:c:cbwd6|CBWD6]]|0.486|
|[[:human genes:n:npipb5|NPIPB5]]|0.482|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.48|
|[[:human genes:t:timeless|TIMELESS]]|0.48|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.479|
|[[:human genes:a:ankle1|ANKLE1]]|0.478|
|[[:human genes:o:ogfr|OGFR]]|0.476|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.475|
|[[:human genes:a:aatf|AATF]]|0.472|
|[[:human genes:s:supt6h|SUPT6H]]|0.471|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.469|
|[[:human genes:u:uqcrh|UQCRH]]|0.468|
|[[:human genes:u:upf1|UPF1]]|0.467|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.467|
|[[:human genes:r:rpl35|RPL35]]|0.467|
|[[:human genes:c:copg1|COPG1]]|0.467|
|[[:human genes:c:ctage4|CTAGE4]]|0.466|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.466|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.466|
|[[:human genes:w:wdr75|WDR75]]|0.466|
|[[:human genes:s:snip1|SNIP1]]|0.465|
|[[:human genes:t:twistnb|TWISTNB]]|0.461|
|[[:human genes:r:rps12|RPS12]]|0.46|
|[[:human genes:s:sec13|SEC13]]|0.459|
|[[:human genes:v:vps54|VPS54]]|0.459|
|[[:human genes:s:stil|STIL]]|0.458|
|[[:human genes:s:slc6a17|SLC6A17]]|0.458|
|[[:human genes:t:tspy1|TSPY1]]|0.457|
|[[:human genes:s:slc4a1|SLC4A1]]|0.456|
|[[:human genes:d:disp2|DISP2]]|0.453|
|[[:human genes:h:hivep3|HIVEP3]]|0.453|
|[[:human genes:p:psmb2|PSMB2]]|0.453|
|[[:human genes:z:zfand5|ZFAND5]]|0.453|
|[[:human genes:r:rad51|RAD51]]|0.452|
|[[:human genes:r:rnf121|RNF121]]|0.452|
|[[:human genes:n:napa|NAPA]]|0.45|
|[[:human genes:e:exosc5|EXOSC5]]|0.449|
|[[:human genes:n:nol10|NOL10]]|0.448|
|[[:human genes:k:kctd17|KCTD17]]|0.448|
|[[:human genes:p:psma7|PSMA7]]|0.446|
|[[:human genes:p:psmc2|PSMC2]]|0.444|
|[[:human genes:m:mbtd1|MBTD1]]|0.444|
|[[:human genes:a:atp1a3|ATP1A3]]|0.443|
|[[:human genes:p:pan2|PAN2]]|0.443|
|[[:human genes:s:syt9|SYT9]]|0.443|
|[[:human genes:p:psmb1|PSMB1]]|0.442|
|[[:human genes:d:ddtl|DDTL]]|0.442|
|[[:human genes:m:med15|MED15]]|0.441|
|[[:human genes:h:hap1|HAP1]]|0.441|
|[[:human genes:i:ik|IK]]|0.438|
|[[:human genes:c:chmp4b|CHMP4B]]|0.438|
|[[:human genes:s:slc38a7|SLC38A7]]|0.438|
|[[:human genes:s:sult1a4|SULT1A4]]|0.437|
|[[:human genes:s:sult1a3|SULT1A3]]|0.437|
|[[:human genes:v:vps28|VPS28]]|0.436|
|[[:human genes:p:pan3|PAN3]]|0.436|
|[[:human genes:c:cdc45|CDC45]]|0.435|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.435|
|[[:human genes:p:pola1|POLA1]]|0.435|
|[[:human genes:r:rrn3|RRN3]]|0.432|
|[[:human genes:t:ticrr|TICRR]]|0.432|
|[[:human genes:a:ankle2|ANKLE2]]|0.431|
|[[:human genes:v:vps52|VPS52]]|0.429|
|[[:human genes:p:psmd3|PSMD3]]|0.429|
|[[:human genes:d:dtl|DTL]]|0.427|
|[[:human genes:t:tsg101|TSG101]]|0.427|
|[[:human genes:p:psmc6|PSMC6]]|0.426|
|[[:human genes:p:psmd7|PSMD7]]|0.425|
|[[:human genes:r:rps14|RPS14]]|0.425|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.425|
|[[:human genes:p:polr2f|POLR2F]]|0.425|
|[[:human genes:s:smg7|SMG7]]|0.424|
|[[:human genes:k:kif3c|KIF3C]]|0.424|
|[[:human genes:c:col2a1|COL2A1]]|0.423|
|[[:human genes:p:polr2h|POLR2H]]|0.423|
|[[:human genes:c:cdh24|CDH24]]|0.423|
|[[:human genes:t:traip|TRAIP]]|0.421|
|[[:human genes:o:orc1|ORC1]]|0.421|
|[[:human genes:k:krt2|KRT2]]|0.42|
|[[:human genes:u:utp3|UTP3]]|0.42|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.419|
|[[:human genes:c:ctage9|CTAGE9]]|0.418|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.418|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.417|
|[[:human genes:t:tyms|TYMS]]|0.416|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.415|
|[[:human genes:m:med29|MED29]]|0.414|
|[[:human genes:i:igfn1|IGFN1]]|0.414|
|[[:human genes:p:prpf19|PRPF19]]|0.413|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.413|
|[[:human genes:u:utp20|UTP20]]|0.413|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.413|
|[[:human genes:s:smg1|SMG1]]|0.412|
|[[:human genes:t:trappc11|TRAPPC11]]|0.412|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.411|
|[[:human genes:c:cln6|CLN6]]|0.41|
|[[:human genes:v:vasn|VASN]]|0.407|
|[[:human genes:t:taf1|TAF1]]|0.406|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:o:orc6|ORC6]]|0.405|
|[[:human genes:m:med17|MED17]]|0.404|
|[[:human genes:p:psmd6|PSMD6]]|0.404|
|[[:human genes:t:tfip11|TFIP11]]|0.404|
|[[:human genes:r:rps2|RPS2]]|0.404|
|[[:human genes:r:rad21|RAD21]]|0.403|
|[[:human genes:k:krt78|KRT78]]|0.402|
|[[:human genes:g:golga6b|GOLGA6B]]|0.402|
|[[:human genes:m:myh7b|MYH7B]]|0.402|
|[[:human genes:n:nup93|NUP93]]|0.402|
|[[:human genes:n:nsf|NSF]]|0.401|
|[[:human genes:y:ythdc1|YTHDC1]]|0.401|
|[[:human genes:m:mfsd12|MFSD12]]|0.401|
|[[:human genes:f:fam25b|FAM25B]]|0.401|
|[[:human genes:c:chaf1a|CHAF1A]]|0.4|
|[[:human genes:p:psmc5|PSMC5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|24/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2D Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>