POLR2G [The Human Chemical-Genetic Interaction Map Project]

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======= POLR2G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2G
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit G
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5436|5436]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62487|P62487]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602013|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA. {ECO:0000250, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol Rpb7 N|
|S1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|RNA polymerase II, core complex|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|translation initiation factor binding|
|positive regulation of translational initiation|
|DNA-directed 5-3 RNA polymerase activity|
|7-methylguanosine mRNA capping|
|7-methylguanosine RNA capping|
|RNA capping|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|positive regulation of viral transcription|
|single-stranded RNA binding|
|positive regulation of mRNA catabolic process|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|positive regulation of mRNA metabolic process|
|regulation of translational initiation|
|fibroblast growth factor receptor signaling pathway|
|P-body|
|regulation of gene silencing by miRNA|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|positive regulation of viral process|
|single-stranded DNA binding|
|cellular response to fibroblast growth factor stimulus|
|nucleotide-excision repair|
|response to fibroblast growth factor|
|positive regulation of translation|
|regulation of gene silencing|
|stem cell population maintenance|
|maintenance of cell number|
|positive regulation of cellular amide metabolic process|
|transcription initiation from RNA polymerase II promoter|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|regulation of viral process|
|mRNA catabolic process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|RNA catabolic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|apoptotic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|positive regulation of cellular protein metabolic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.49|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.75|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.79|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.86|
|[[:results:exp219|A-395N 10μM R05 exp219]]|1.92|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.92|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.498|
|[[:human genes:p:polr2j3|POLR2J3]]|0.49|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.424|
|[[:human genes:s:supt6h|SUPT6H]]|0.417|
|[[:human genes:c:copb2|COPB2]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 614/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|25/28|
|bone|19/25|
|breast|29/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|14/21|
|liver|19/20|
|lung|60/75|
|lymphocyte|12/14|
|ovary|24/26|
|pancreas|20/24|
|peripheral nervous system|13/16|
|plasma cell|12/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 816
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2G Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>