POLR2J [The Human Chemical-Genetic Interaction Map Project]

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======= POLR2J =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POLR2J
  * **<color #00a2e8>Official Name</color>**: RNA polymerase II subunit J
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5439|5439]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52435|P52435]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POLR2J&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POLR2J|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604150|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250, ECO:0000269|PubMed:9852112}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RNA pol L|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|LRR domain binding|
|RNA polymerase II activity|
|RNA polymerase II, core complex|
|DNA-directed 5-3 RNA polymerase activity|
|7-methylguanosine mRNA capping|
|RNA capping|
|7-methylguanosine RNA capping|
|positive regulation of viral transcription|
|regulation of viral transcription|
|somatic stem cell population maintenance|
|snRNA transcription by RNA polymerase II|
|snRNA transcription|
|transcription-coupled nucleotide-excision repair|
|transcription elongation from RNA polymerase II promoter|
|fibroblast growth factor receptor signaling pathway|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|DNA-templated transcription, elongation|
|ncRNA transcription|
|positive regulation of viral process|
|cellular response to fibroblast growth factor stimulus|
|nucleotide-excision repair|
|response to fibroblast growth factor|
|regulation of gene silencing|
|stem cell population maintenance|
|maintenance of cell number|
|protein dimerization activity|
|transcription initiation from RNA polymerase II promoter|
|regulation of viral process|
|DNA-templated transcription, initiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|DNA metabolic process|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|RNA processing|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|DNA binding|
|response to endogenous stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.2|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.18|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.13|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.07|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.01|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.98|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.97|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.94|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.9|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.88|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.82|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.76|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.74|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.72|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.7|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.72|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.74|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.78|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.87|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.92|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.99|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.99|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|2.12|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|2.31|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.38|
|[[:results:exp340|BN82002 4μM R07 exp340]]|2.62|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|3.14|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:slc4a1|SLC4A1]]|0.472|
|[[:human genes:p:prim1|PRIM1]]|0.47|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.469|
|[[:human genes:r:rrm1|RRM1]]|0.46|
|[[:human genes:s:supt6h|SUPT6H]]|0.46|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.448|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.438|
|[[:human genes:t:twistnb|TWISTNB]]|0.435|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.433|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.432|
|[[:human genes:c:cdca3|CDCA3]]|0.431|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.43|
|[[:human genes:s:supt5h|SUPT5H]]|0.43|
|[[:human genes:m:med14|MED14]]|0.427|
|[[:human genes:p:pola2|POLA2]]|0.427|
|[[:human genes:t:tspy8|TSPY8]]|0.423|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.417|
|[[:human genes:t:tyms|TYMS]]|0.416|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.416|
|[[:human genes:n:nup43|NUP43]]|0.412|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.41|
|[[:human genes:t:ticrr|TICRR]]|0.407|
|[[:human genes:w:wapal|WAPAL]]|0.404|
|[[:human genes:p:psmb3|PSMB3]]|0.404|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 662
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POLR2J Expression in NALM6 Cells: 4.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>