POP1 [The Human Chemical-Genetic Interaction Map Project]

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======= POP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POP1
  * **<color #00a2e8>Official Name</color>**: POP1 homolog, ribonuclease P/MRP subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10940|10940]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99575|Q99575]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602486|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|POP1|
|POPLD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ribonuclease MRP activity|
|nucleolar ribonuclease P complex|
|ribonuclease MRP complex|
|tRNA catabolic process|
|multimeric ribonuclease P complex|
|ribonuclease P RNA binding|
|ribonuclease P activity|
|tRNA 5-leader removal|
|tRNA 5-end processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|ncRNA catabolic process|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|tRNA processing|
|RNA phosphodiester bond hydrolysis|
|tRNA metabolic process|
|RNA catabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|extracellular space|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.94|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|1.71|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|1.81|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2.13|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.15|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmd3|PSMD3]]|0.444|
|[[:human genes:p:polr2j3|POLR2J3]]|0.435|
|[[:human genes:p:psmd1|PSMD1]]|0.423|
|[[:human genes:l:lrr1|LRR1]]|0.419|
|[[:human genes:c:chd4|CHD4]]|0.418|
|[[:human genes:s:ssh2|SSH2]]|0.412|
|[[:human genes:d:ddtl|DDTL]]|0.405|
|[[:human genes:c:cdc45|CDC45]]|0.404|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.404|
|[[:human genes:k:kctd17|KCTD17]]|0.402|
|[[:human genes:p:psma6|PSMA6]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 138/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|2/28|
|bone|5/26|
|breast|1/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|0/16|
|kidney|5/21|
|liver|5/20|
|lung|17/75|
|lymphocyte|2/16|
|ovary|7/26|
|pancreas|4/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POP1 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>