POSTN [The Human Chemical-Genetic Interaction Map Project]

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======= POSTN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: POSTN
  * **<color #00a2e8>Official Name</color>**: periostin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10631|10631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15063|Q15063]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=POSTN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20POSTN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608777|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fasciclin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to vitamin K|
|positive regulation of chemokine (C-C motif) ligand 2 secretion|
|regulation of chemokine (C-C motif) ligand 2 secretion|
|bone regeneration|
|response to vitamin K|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|negative regulation of substrate adhesion-dependent cell spreading|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|response to muscle activity|
|cellular response to vitamin|
|positive regulation of smooth muscle cell migration|
|negative regulation of cell-matrix adhesion|
|regulation of substrate adhesion-dependent cell spreading|
|positive regulation of chemokine production|
|cell adhesion molecule binding|
|neuron projection extension|
|regulation of smooth muscle cell migration|
|negative regulation of cell-substrate adhesion|
|tissue regeneration|
|response to activity|
|cellular response to nutrient|
|neuromuscular junction|
|regulation of chemokine production|
|response to vitamin|
|developmental cell growth|
|cell growth|
|regulation of systemic arterial blood pressure|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of Notch signaling pathway|
|cellular response to fibroblast growth factor stimulus|
|developmental growth involved in morphogenesis|
|regulation of cell-matrix adhesion|
|response to fibroblast growth factor|
|extracellular matrix structural constituent|
|response to estradiol|
|positive regulation of cytokine secretion|
|cellular response to transforming growth factor beta stimulus|
|regeneration|
|response to transforming growth factor beta|
|trans-Golgi network|
|heparin binding|
|regulation of blood pressure|
|regulation of cytokine secretion|
|regulation of cell-substrate adhesion|
|response to mechanical stimulus|
|response to nutrient|
|extracellular matrix|
|cellular response to nutrient levels|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|positive regulation of peptide secretion|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cell development|
|cellular response to external stimulus|
|extracellular matrix organization|
|response to hypoxia|
|response to decreased oxygen levels|
|collagen-containing extracellular matrix|
|response to oxygen levels|
|extracellular structure organization|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|response to nutrient levels|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|positive regulation of cell motility|
|response to growth factor|
|response to extracellular stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|response to wounding|
|neuron projection development|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cellular component organization|
|regulation of protein transport|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|regulation of cell migration|
|response to lipid|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.33|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='POSTN Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>