PPA1 [The Human Chemical-Genetic Interaction Map Project]

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======= PPA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPA1
  * **<color #00a2e8>Official Name</color>**: inorganic pyrophosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5464|5464]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15181|Q15181]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/179030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyrophosphatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|diphosphate metabolic process|
|inorganic diphosphatase activity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|magnesium ion binding|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.89|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.83|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.75|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.71|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.73|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.74|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.75|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.76|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.8|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.82|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.83|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.83|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.86|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.01|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.02|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.09|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.25|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|2.3|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.43|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.57|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmvk|PMVK]]|0.523|
|[[:human genes:f:fh|FH]]|0.499|
|[[:human genes:p:ppcdc|PPCDC]]|0.498|
|[[:human genes:t:trmt61a|TRMT61A]]|0.465|
|[[:human genes:g:gemin6|GEMIN6]]|0.462|
|[[:human genes:g:gemin4|GEMIN4]]|0.461|
|[[:human genes:d:ddx39a|DDX39A]]|0.448|
|[[:human genes:r:rft1|RFT1]]|0.435|
|[[:human genes:d:dnlz|DNLZ]]|0.433|
|[[:human genes:g:gemin8|GEMIN8]]|0.43|
|[[:human genes:t:ten1|TEN1]]|0.428|
|[[:human genes:r:rpia|RPIA]]|0.423|
|[[:human genes:m:mettl1|METTL1]]|0.422|
|[[:human genes:p:pgm3|PGM3]]|0.42|
|[[:human genes:t:trmt6|TRMT6]]|0.412|
|[[:human genes:c:c15orf41|C15orf41]]|0.41|
|[[:human genes:g:gemin7|GEMIN7]]|0.407|
|[[:human genes:l:lsm10|LSM10]]|0.407|
|[[:human genes:a:atic|ATIC]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 583/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|22/28|
|bone|23/26|
|breast|16/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|18/21|
|liver|16/20|
|lung|55/75|
|lymphocyte|11/16|
|ovary|17/26|
|pancreas|21/24|
|peripheral nervous system|14/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|23/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 715
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPA1 Expression in NALM6 Cells: 7.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>