PPCDC [The Human Chemical-Genetic Interaction Map Project]

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======= PPCDC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPCDC
  * **<color #00a2e8>Official Name</color>**: phosphopantothenoylcysteine decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=60490|60490]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CD2|Q96CD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPCDC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPCDC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609854|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine. {ECO:0000269|PubMed:11923312, ECO:0000269|PubMed:15581364}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Flavoprotein|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphopantothenoylcysteine decarboxylase activity|
|coenzyme A biosynthetic process|
|coenzyme A metabolic process|
|ribonucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate biosynthetic process|
|nucleoside bisphosphate biosynthetic process|
|purine nucleoside bisphosphate metabolic process|
|nucleoside bisphosphate metabolic process|
|ribonucleoside bisphosphate metabolic process|
|coenzyme biosynthetic process|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cofactor biosynthetic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.11|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.06|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.95|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.92|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-1.72|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.71|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmvk|PMVK]]|0.722|
|[[:human genes:p:pgm3|PGM3]]|0.636|
|[[:human genes:d:dnlz|DNLZ]]|0.614|
|[[:human genes:t:trmt61a|TRMT61A]]|0.613|
|[[:human genes:d:dhrsx|DHRSX]]|0.608|
|[[:human genes:t:trmt6|TRMT6]]|0.569|
|[[:human genes:s:srd5a3|SRD5A3]]|0.566|
|[[:human genes:p:ppcs|PPCS]]|0.539|
|[[:human genes:m:mettl1|METTL1]]|0.529|
|[[:human genes:t:ten1|TEN1]]|0.52|
|[[:human genes:l:lsm10|LSM10]]|0.516|
|[[:human genes:f:fh|FH]]|0.506|
|[[:human genes:p:ptar1|PTAR1]]|0.503|
|[[:human genes:r:rft1|RFT1]]|0.502|
|[[:human genes:p:ppa1|PPA1]]|0.498|
|[[:human genes:r:rpia|RPIA]]|0.493|
|[[:human genes:g:gemin6|GEMIN6]]|0.491|
|[[:human genes:t:thg1l|THG1L]]|0.487|
|[[:human genes:f:fkbpl|FKBPL]]|0.483|
|[[:human genes:g:gemin8|GEMIN8]]|0.482|
|[[:human genes:y:yars2|YARS2]]|0.468|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.467|
|[[:human genes:g:gemin7|GEMIN7]]|0.466|
|[[:human genes:c:c1d|C1D]]|0.464|
|[[:human genes:d:dolk|DOLK]]|0.463|
|[[:human genes:d:ddx39a|DDX39A]]|0.463|
|[[:human genes:n:n6amt1|N6AMT1]]|0.461|
|[[:human genes:p:ppp6c|PPP6C]]|0.459|
|[[:human genes:g:g6pd|G6PD]]|0.456|
|[[:human genes:p:pus3|PUS3]]|0.456|
|[[:human genes:m:mrpl21|MRPL21]]|0.453|
|[[:human genes:t:tube1|TUBE1]]|0.452|
|[[:human genes:n:nars2|NARS2]]|0.452|
|[[:human genes:r:rabggtb|RABGGTB]]|0.452|
|[[:human genes:a:alg6|ALG6]]|0.449|
|[[:human genes:d:dap3|DAP3]]|0.445|
|[[:human genes:p:pars2|PARS2]]|0.445|
|[[:human genes:r:rpp21|RPP21]]|0.445|
|[[:human genes:t:tsen15|TSEN15]]|0.444|
|[[:human genes:s:sepsecs|SEPSECS]]|0.442|
|[[:human genes:n:nbn|NBN]]|0.442|
|[[:human genes:a:atxn10|ATXN10]]|0.441|
|[[:human genes:m:msto1|MSTO1]]|0.44|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.44|
|[[:human genes:t:tubd1|TUBD1]]|0.44|
|[[:human genes:r:rfk|RFK]]|0.44|
|[[:human genes:c:c15orf41|C15orf41]]|0.438|
|[[:human genes:z:zrsr2|ZRSR2]]|0.43|
|[[:human genes:z:zcrb1|ZCRB1]]|0.43|
|[[:human genes:l:lars2|LARS2]]|0.427|
|[[:human genes:t:tpk1|TPK1]]|0.425|
|[[:human genes:a:alg1|ALG1]]|0.425|
|[[:human genes:t:tmem242|TMEM242]]|0.424|
|[[:human genes:e:ears2|EARS2]]|0.423|
|[[:human genes:k:kdsr|KDSR]]|0.422|
|[[:human genes:c:cxorf56|CXorf56]]|0.422|
|[[:human genes:s:srp14|SRP14]]|0.422|
|[[:human genes:t:ttc4|TTC4]]|0.421|
|[[:human genes:s:selrc1|SELRC1]]|0.421|
|[[:human genes:c:cep57|CEP57]]|0.421|
|[[:human genes:p:ppa2|PPA2]]|0.42|
|[[:human genes:m:mrps5|MRPS5]]|0.419|
|[[:human genes:t:tamm41|TAMM41]]|0.416|
|[[:human genes:e:elp6|ELP6]]|0.415|
|[[:human genes:g:gemin4|GEMIN4]]|0.414|
|[[:human genes:a:atic|ATIC]]|0.412|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.411|
|[[:human genes:s:ssb|SSB]]|0.41|
|[[:human genes:g:gatc|GATC]]|0.409|
|[[:human genes:m:mrps6|MRPS6]]|0.409|
|[[:human genes:d:dohh|DOHH]]|0.406|
|[[:human genes:p:pgs1|PGS1]]|0.405|
|[[:human genes:t:tkt|TKT]]|0.404|
|[[:human genes:m:mre11a|MRE11A]]|0.403|
|[[:human genes:s:sco2|SCO2]]|0.401|
|[[:human genes:p:psmg2|PSMG2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 14/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 887
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPCDC Expression in NALM6 Cells: 3.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>