PPIAL4F [The Human Chemical-Genetic Interaction Map Project]

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======= PPIAL4F =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIAL4F
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase A like 4F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=728945|728945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DN26|P0DN26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIAL4F&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIAL4F|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cyclosporin A binding|
|protein refolding|
|protein peptidyl-prolyl isomerization|
|peptidyl-prolyl cis-trans isomerase activity|
|peptidyl-proline modification|
|unfolded protein binding|
|protein folding|
|peptidyl-amino acid modification|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|-1.77|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.76|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIAL4F Expression in NALM6 Cells: 1.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>