PPIL4 [The Human Chemical-Genetic Interaction Map Project]

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======= PPIL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPIL4
  * **<color #00a2e8>Official Name</color>**: peptidylprolyl isomerase like 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85313|85313]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUA2|Q8WUA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPIL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPIL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pro isomerase|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of phosphorylation of RNA polymerase II C-terminal domain|
|peptidyl-prolyl cis-trans isomerase activity|
|protein peptidyl-prolyl isomerization|
|peptidyl-proline modification|
|peptidyl-amino acid modification|
|RNA binding|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.21|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.1|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.99|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.94|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.92|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.86|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.74|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.86|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 362/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|10/28|
|bone|10/26|
|breast|14/33|
|central nervous system|40/56|
|cervix|4/4|
|colorectal|5/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|7/21|
|liver|4/20|
|lung|31/75|
|lymphocyte|12/16|
|ovary|19/26|
|pancreas|12/24|
|peripheral nervous system|12/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|10/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2877
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPIL4 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>