PPP1R13B [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R13B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R13B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 13B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23368|23368]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96KQ4|Q96KQ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R13B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R13B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606455|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. {ECO:0000269|PubMed:11684014}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|Ank|
|Ank 2|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|positive regulation of establishment of protein localization to mitochondrion|
|p53 binding|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|positive regulation of neuron death|
|positive regulation of mitochondrion organization|
|signal transduction by p53 class mediator|
|positive regulation of protein localization to membrane|
|mitochondrial membrane organization|
|intrinsic apoptotic signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of signal transduction by p53 class mediator|
|regulation of protein localization to membrane|
|mitochondrial transport|
|apoptotic signaling pathway|
|regulation of neuron death|
|positive regulation of cellular protein localization|
|transcription factor binding|
|regulation of apoptotic signaling pathway|
|mitochondrion organization|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|negative regulation of cell cycle|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of transport|
|regulation of protein localization|
|programmed cell death|
|cell death|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15179
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R13B Expression in NALM6 Cells: 3.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>