PPP1R15A [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R15A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R15A
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 15A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23645|23645]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75807|O75807]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R15A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R15A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. {ECO:0000269|PubMed:11564868, ECO:0000269|PubMed:12556489, ECO:0000269|PubMed:14635196, ECO:0000269|PubMed:14718519, ECO:0000269|PubMed:8139541}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PP1c bdg|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation|
|regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation|
|regulation of translational initiation by eIF2 alpha dephosphorylation|
|positive regulation of peptidyl-serine dephosphorylation|
|positive regulation of translational initiation in response to stress|
|negative regulation of PERK-mediated unfolded protein response|
|regulation of peptidyl-serine dephosphorylation|
|positive regulation of translation in response to stress|
|regulation of translational initiation in response to stress|
|protein phosphatase type 1 complex|
|regulation of PERK-mediated unfolded protein response|
|negative regulation of endoplasmic reticulum unfolded protein response|
|protein phosphatase activator activity|
|regulation of translation in response to stress|
|protein phosphatase 1 binding|
|positive regulation of phosphoprotein phosphatase activity|
|regulation of endoplasmic reticulum unfolded protein response|
|positive regulation of translational initiation|
|protein phosphatase regulator activity|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|positive regulation of phosphatase activity|
|positive regulation of response to endoplasmic reticulum stress|
|positive regulation of protein dephosphorylation|
|negative regulation of response to endoplasmic reticulum stress|
|positive regulation of dephosphorylation|
|negative regulation of phosphoprotein phosphatase activity|
|negative regulation of protein dephosphorylation|
|regulation of translational initiation|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|positive regulation of translation|
|protein localization to endoplasmic reticulum|
|regulation of protein dephosphorylation|
|cell cycle arrest|
|intrinsic apoptotic signaling pathway|
|positive regulation of cellular amide metabolic process|
|mitochondrial outer membrane|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|protein dephosphorylation|
|response to endoplasmic reticulum stress|
|apoptotic signaling pathway|
|dephosphorylation|
|regulation of translation|
|regulation of cellular component size|
|regulation of cellular amide metabolic process|
|negative regulation of hydrolase activity|
|protein kinase binding|
|regulation of anatomical structure size|
|posttranscriptional regulation of gene expression|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|regulation of cellular response to stress|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|apoptotic process|
|endoplasmic reticulum membrane|
|Golgi apparatus|
|cell cycle process|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of response to stress|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.19|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.7|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.74|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.82|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.21|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.37|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R15A Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>