PPP1R2 [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R2
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory inhibitor subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5504|5504]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41236|P41236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601792|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Inhibitor of protein-phosphatase 1.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IPP-2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein serine/threonine phosphatase inhibitor activity|
|protein phosphatase inhibitor activity|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|negative regulation of phosphoprotein phosphatase activity|
|energy reserve metabolic process|
|negative regulation of protein dephosphorylation|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|regulation of phosphoprotein phosphatase activity|
|regulation of protein dephosphorylation|
|cellular carbohydrate metabolic process|
|regulation of phosphatase activity|
|regulation of dephosphorylation|
|energy derivation by oxidation of organic compounds|
|generation of precursor metabolites and energy|
|negative regulation of hydrolase activity|
|carbohydrate metabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|negative regulation of catalytic activity|
|oxidation-reduction process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.93|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.82|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ppp1ca|PPP1CA]]|0.469|
|[[:human genes:p:ppp1cc|PPP1CC]]|0.424|
|[[:human genes:a:atat1|ATAT1]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 554/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|25/28|
|blood|15/28|
|bone|17/26|
|breast|20/33|
|central nervous system|43/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|12/13|
|fibroblast|0/1|
|gastric|12/16|
|kidney|17/21|
|liver|14/20|
|lung|58/75|
|lymphocyte|7/16|
|ovary|22/26|
|pancreas|22/24|
|peripheral nervous system|7/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|1/2|
|upper aerodigestive|18/22|
|urinary tract|23/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R2 Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>