PPP1R9B [The Human Chemical-Genetic Interaction Map Project]

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======= PPP1R9B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP1R9B
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 1 regulatory subunit 9B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84687|84687]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96SB3|Q96SB3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP1R9B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP1R9B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha- adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)- induced cell migration. {ECO:0000250, ECO:0000269|PubMed:19151759}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of opioid receptor signaling pathway|
|regulation of cell growth by extracellular stimulus|
|cellular response to morphine|
|cellular response to isoquinoline alkaloid|
|protein phosphatase type 1 complex|
|filopodium assembly|
|regulation of exit from mitosis|
|protein phosphatase 1 binding|
|response to isoquinoline alkaloid|
|response to morphine|
|protein phosphatase inhibitor activity|
|cellular response to alkaloid|
|negative regulation of phosphoprotein phosphatase activity|
|adherens junction|
|negative regulation of protein dephosphorylation|
|filopodium|
|response to anesthetic|
|ruffle membrane|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|response to alkaloid|
|regulation of phosphoprotein phosphatase activity|
|cellular response to ammonium ion|
|regulation of protein dephosphorylation|
|regulation of G protein-coupled receptor signaling pathway|
|calcium-mediated signaling|
|cell cycle arrest|
|dendritic spine|
|regulation of mitotic nuclear division|
|regulation of phosphatase activity|
|lamellipodium|
|negative regulation of cell growth|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|regulation of nuclear division|
|actin filament binding|
|regulation of dephosphorylation|
|actin cytoskeleton|
|actin filament organization|
|negative regulation of growth|
|postsynaptic density|
|cellular response to extracellular stimulus|
|response to xenobiotic stimulus|
|cellular response to external stimulus|
|second-messenger-mediated signaling|
|RNA splicing|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|supramolecular fiber organization|
|cell projection assembly|
|actin cytoskeleton organization|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|actin filament-based process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of growth|
|regulation of cell cycle process|
|negative regulation of catalytic activity|
|neuron development|
|RNA processing|
|response to organic cyclic compound|
|cell migration|
|cell cycle process|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|negative regulation of cellular protein metabolic process|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|response to endogenous stimulus|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|RNA metabolic process|
|intracellular signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.17|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6741
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP1R9B Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>