PPP3CB [The Human Chemical-Genetic Interaction Map Project]

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======= PPP3CB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP3CB
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 3 catalytic subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5532|5532]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16298|P16298]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP3CB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP3CB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114106|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calmodulin-dependent protein phosphatase activity|
|calcineurin complex|
|locomotion involved in locomotory behavior|
|protein phosphatase 2B binding|
|negative regulation of T cell mediated cytotoxicity|
|lymphangiogenesis|
|calcineurin-NFAT signaling cascade|
|lymph vessel morphogenesis|
|calcineurin-mediated signaling|
|regulation of synaptic vesicle endocytosis|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of T cell mediated immunity|
|lymph vessel development|
|negative regulation of cell killing|
|regulation of synaptic vesicle recycling|
|inositol phosphate-mediated signaling|
|T cell homeostasis|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|regulation of T cell mediated cytotoxicity|
|axon extension|
|Wnt signaling pathway, calcium modulating pathway|
|T cell proliferation|
|negative regulation of lymphocyte mediated immunity|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|calcium-ion regulated exocytosis|
|T-tubule|
|negative regulation of adaptive immune response|
|negative regulation of leukocyte mediated immunity|
|lymphocyte homeostasis|
|drug binding|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|neuron projection extension|
|protein serine/threonine phosphatase activity|
|leukocyte homeostasis|
|regulation of T cell mediated immunity|
|positive regulation of insulin secretion|
|regulation of leukocyte mediated cytotoxicity|
|lymphocyte proliferation|
|mononuclear cell proliferation|
|developmental cell growth|
|cell growth|
|positive regulation of peptide hormone secretion|
|leukocyte proliferation|
|regulation of cell killing|
|regulation of synaptic vesicle cycle|
|developmental growth involved in morphogenesis|
|memory|
|negative regulation of immune effector process|
|positive regulation of hormone secretion|
|Z disc|
|non-canonical Wnt signaling pathway|
|T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|learning|
|calcium-mediated signaling|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|protein dimerization activity|
|regulation of adaptive immune response|
|Fc-epsilon receptor signaling pathway|
|regulation of insulin secretion|
|regulation of synaptic plasticity|
|locomotory behavior|
|homeostasis of number of cells|
|calmodulin binding|
|regulation of leukocyte mediated immunity|
|regulation of endocytosis|
|regulation of peptide hormone secretion|
|protein dephosphorylation|
|T cell activation|
|lymphocyte differentiation|
|Fc receptor signaling pathway|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|cognition|
|dephosphorylation|
|leukocyte differentiation|
|second-messenger-mediated signaling|
|glutamatergic synapse|
|enzyme binding|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|axonogenesis|
|lymphocyte activation|
|developmental growth|
|growth|
|cellular response to drug|
|positive regulation of secretion by cell|
|axon development|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of secretion|
|negative regulation of immune system process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of peptide secretion|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|heart development|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|behavior|
|immune response-regulating signaling pathway|
|hematopoietic or lymphoid organ development|
|immune system development|
|neuron projection development|
|regulated exocytosis|
|regulation of protein transport|
|calcium ion binding|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|neuron development|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cellular localization|
|leukocyte activation|
|protein phosphorylation|
|positive regulation of transport|
|secretion by cell|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|export from cell|
|cell activation|
|response to cytokine|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|secretion|
|regulation of immune response|
|cell projection organization|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|locomotion|
|nervous system process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18600
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP3CB Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>