PPP4C [The Human Chemical-Genetic Interaction Map Project]

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======= PPP4C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PPP4C
  * **<color #00a2e8>Official Name</color>**: protein phosphatase 4 catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5531|5531]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60510|P60510]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PPP4C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PPP4C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:12934076, ECO:0000269|PubMed:1336397, ECO:0000269|PubMed:15805470, ECO:0000269|PubMed:18347064, ECO:0000269|PubMed:18487071, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:18758438, ECO:0000269|PubMed:20154705}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Metallophos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein phosphatase 4 complex|
|NF-kappaB-inducing kinase activity|
|regulation of double-strand break repair via homologous recombination|
|protein serine/threonine phosphatase activity|
|regulation of double-strand break repair|
|NIK/NF-kappaB signaling|
|regulation of DNA recombination|
|regulation of DNA repair|
|microtubule organizing center|
|protein dephosphorylation|
|regulation of response to DNA damage stimulus|
|dephosphorylation|
|regulation of DNA metabolic process|
|regulation of cellular response to stress|
|regulation of response to stress|
|intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.15|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-1.96|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.95|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.75|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.75|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.74|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rtcb|RTCB]]|0.558|
|[[:human genes:g:gnb1l|GNB1L]]|0.537|
|[[:human genes:t:thg1l|THG1L]]|0.531|
|[[:human genes:g:gemin8|GEMIN8]]|0.526|
|[[:human genes:r:rptor|RPTOR]]|0.525|
|[[:human genes:a:adsl|ADSL]]|0.519|
|[[:human genes:u:uhrf1|UHRF1]]|0.515|
|[[:human genes:t:tti1|TTI1]]|0.512|
|[[:human genes:r:rpp21|RPP21]]|0.508|
|[[:human genes:u:uap1|UAP1]]|0.508|
|[[:human genes:t:trmt5|TRMT5]]|0.505|
|[[:human genes:d:dpagt1|DPAGT1]]|0.503|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.498|
|[[:human genes:a:alg1|ALG1]]|0.498|
|[[:human genes:p:pmm2|PMM2]]|0.496|
|[[:human genes:m:med16|MED16]]|0.495|
|[[:human genes:a:alg13|ALG13]]|0.495|
|[[:human genes:t:tti2|TTI2]]|0.492|
|[[:human genes:l:lsm10|LSM10]]|0.491|
|[[:human genes:g:gmppb|GMPPB]]|0.49|
|[[:human genes:d:ddx20|DDX20]]|0.489|
|[[:human genes:s:srp14|SRP14]]|0.488|
|[[:human genes:d:dohh|DOHH]]|0.487|
|[[:human genes:g:gemin6|GEMIN6]]|0.486|
|[[:human genes:t:telo2|TELO2]]|0.485|
|[[:human genes:s:snapc5|SNAPC5]]|0.483|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.483|
|[[:human genes:p:ppp6c|PPP6C]]|0.482|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.481|
|[[:human genes:h:hars|HARS]]|0.477|
|[[:human genes:f:fnta|FNTA]]|0.476|
|[[:human genes:g:gfpt1|GFPT1]]|0.474|
|[[:human genes:f:fh|FH]]|0.474|
|[[:human genes:a:atxn10|ATXN10]]|0.474|
|[[:human genes:a:aars|AARS]]|0.472|
|[[:human genes:r:rabggtb|RABGGTB]]|0.472|
|[[:human genes:z:zrsr2|ZRSR2]]|0.468|
|[[:human genes:c:cdipt|CDIPT]]|0.467|
|[[:human genes:c:c15orf41|C15orf41]]|0.467|
|[[:human genes:r:rnmt|RNMT]]|0.465|
|[[:human genes:t:tsen54|TSEN54]]|0.462|
|[[:human genes:e:exoc4|EXOC4]]|0.462|
|[[:human genes:v:vrk1|VRK1]]|0.46|
|[[:human genes:r:rpe|RPE]]|0.46|
|[[:human genes:c:ccdc115|CCDC115]]|0.454|
|[[:human genes:t:ten1|TEN1]]|0.453|
|[[:human genes:t:tbcb|TBCB]]|0.453|
|[[:human genes:c:cct7|CCT7]]|0.451|
|[[:human genes:t:tbca|TBCA]]|0.445|
|[[:human genes:b:bub3|BUB3]]|0.443|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.442|
|[[:human genes:n:nae1|NAE1]]|0.44|
|[[:human genes:s:smek1|SMEK1]]|0.438|
|[[:human genes:u:urm1|URM1]]|0.436|
|[[:human genes:u:utp23|UTP23]]|0.435|
|[[:human genes:c:ctc1|CTC1]]|0.435|
|[[:human genes:v:vezt|VEZT]]|0.434|
|[[:human genes:r:rbm14|RBM14]]|0.433|
|[[:human genes:n:naa20|NAA20]]|0.432|
|[[:human genes:p:polr3h|POLR3H]]|0.431|
|[[:human genes:r:rnaseh2b|RNASEH2B]]|0.431|
|[[:human genes:z:zcrb1|ZCRB1]]|0.43|
|[[:human genes:t:tprkb|TPRKB]]|0.429|
|[[:human genes:t:triap1|TRIAP1]]|0.429|
|[[:human genes:a:atp5j|ATP5J]]|0.426|
|[[:human genes:u:uba3|UBA3]]|0.426|
|[[:human genes:h:haus8|HAUS8]]|0.423|
|[[:human genes:d:ddx1|DDX1]]|0.423|
|[[:human genes:p:ppcs|PPCS]]|0.423|
|[[:human genes:n:nsmce1|NSMCE1]]|0.422|
|[[:human genes:p:ppa2|PPA2]]|0.422|
|[[:human genes:e:elp3|ELP3]]|0.421|
|[[:human genes:d:dolk|DOLK]]|0.42|
|[[:human genes:p:pelo|PELO]]|0.417|
|[[:human genes:w:wdr77|WDR77]]|0.414|
|[[:human genes:p:pggt1b|PGGT1B]]|0.413|
|[[:human genes:c:ciao1|CIAO1]]|0.412|
|[[:human genes:f:fen1|FEN1]]|0.41|
|[[:human genes:y:yars|YARS]]|0.41|
|[[:human genes:o:otud5|OTUD5]]|0.409|
|[[:human genes:f:fntb|FNTB]]|0.409|
|[[:human genes:d:dhps|DHPS]]|0.409|
|[[:human genes:s:slc25a19|SLC25A19]]|0.408|
|[[:human genes:t:taf1a|TAF1A]]|0.408|
|[[:human genes:u:uxt|UXT]]|0.408|
|[[:human genes:c:cbfb|CBFB]]|0.407|
|[[:human genes:c:c11orf57|C11orf57]]|0.407|
|[[:human genes:x:xpot|XPOT]]|0.406|
|[[:human genes:w:wdr24|WDR24]]|0.406|
|[[:human genes:e:eif3f|EIF3F]]|0.404|
|[[:human genes:c:chchd4|CHCHD4]]|0.403|
|[[:human genes:e:eprs|EPRS]]|0.402|
|[[:human genes:r:rpia|RPIA]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 633/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|22/28|
|bone|24/26|
|breast|27/33|
|central nervous system|48/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|19/21|
|liver|17/20|
|lung|63/75|
|lymphocyte|14/16|
|ovary|22/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|27/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 803
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PPP4C Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>