PRAMEF25 [The Human Chemical-Genetic Interaction Map Project]

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======= PRAMEF25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRAMEF25
  * **<color #00a2e8>Official Name</color>**: PRAME family member 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=441873|441873]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NGN4|A6NGN4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRAMEF25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRAMEF25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of cell differentiation|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|negative regulation of cell death|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|regulation of cell death|
|negative regulation of gene expression|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-4.31|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-4.24|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-3.41|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-3.12|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-3|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.97|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.93|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.92|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.89|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.87|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-2.81|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.78|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2.75|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.72|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.68|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.65|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.65|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.62|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.55|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.38|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.37|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.31|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.24|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-2.22|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.21|
|[[:results:exp136|MS094 2μM R03 exp136]]|-2.2|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.2|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.19|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.18|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.17|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.13|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-2.1|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.04|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-2.04|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.03|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.95|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.94|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.94|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.93|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.9|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.88|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.86|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.86|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.84|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|-1.84|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.83|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|-1.81|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.78|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-1.77|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.76|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.74|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.7|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.7|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.79|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.8|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.86|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.91|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.02|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.16|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.19|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|2.29|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.38|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2.63|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.65|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.98|
|[[:results:exp135|MS023 7μM R03 exp135]]|3.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11674
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRAMEF25 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>