PRCP [The Human Chemical-Genetic Interaction Map Project]

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======= PRCP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRCP
  * **<color #00a2e8>Official Name</color>**: prolylcarboxypeptidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5547|5547]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42785|P42785]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRCP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRCP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase S28|
|Abhydrolase 6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasma kallikrein-kinin cascade|
|kinin cascade|
|regulation of thyroid hormone mediated signaling pathway|
|serine-type carboxypeptidase activity|
|basal part of cell|
|angiogenesis involved in wound healing|
|dipeptidyl-peptidase activity|
|blood coagulation, intrinsic pathway|
|negative regulation of systemic arterial blood pressure|
|blood coagulation, fibrin clot formation|
|protein activation cascade|
|energy homeostasis|
|negative regulation of blood pressure|
|azurophil granule membrane|
|ficolin-1-rich granule membrane|
|acute inflammatory response|
|regulation of blood vessel endothelial cell migration|
|regulation of systemic arterial blood pressure|
|regulation of endothelial cell migration|
|regulation of reactive oxygen species metabolic process|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of epithelial cell migration|
|blood coagulation|
|coagulation|
|hemostasis|
|angiogenesis|
|multicellular organismal homeostasis|
|blood circulation|
|circulatory system process|
|blood vessel morphogenesis|
|wound healing|
|blood vessel development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|vasculature development|
|myeloid leukocyte mediated immunity|
|cardiovascular system development|
|myeloid cell activation involved in immune response|
|response to wounding|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|leukocyte activation|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|proteolysis|
|defense response|
|homeostatic process|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.08|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRCP Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>