PRDM10 [The Human Chemical-Genetic Interaction Map Project]

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======= PRDM10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDM10
  * **<color #00a2e8>Official Name</color>**: PR/SET domain 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56980|56980]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQV6|Q9NQV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDM10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDM10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618319|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA polymerase II core promoter sequence-specific DNA binding|
|histone methyltransferase complex|
|methyltransferase activity|
|methylation|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.25|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.11|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.99|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.97|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.89|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.86|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.84|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.82|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.75|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.74|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.72|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.71|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.75|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/25|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2096
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDM10 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>