PRDM1 [The Human Chemical-Genetic Interaction Map Project]

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======= PRDM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDM1
  * **<color #00a2e8>Official Name</color>**: PR/SET domain 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=639|639]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75626|O75626]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B- lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sebum secreting cell proliferation|
|regulation of extrathymic T cell differentiation|
|regulation of NK T cell differentiation|
|intestinal epithelial cell development|
|trophoblast giant cell differentiation|
|regulation of natural killer cell differentiation|
|intestinal epithelial cell differentiation|
|cell differentiation involved in embryonic placenta development|
|regulation of natural killer cell activation|
|eye photoreceptor cell development|
|maternal placenta development|
|eye photoreceptor cell differentiation|
|coronary vasculature development|
|photoreceptor cell development|
|columnar/cuboidal epithelial cell development|
|promoter-specific chromatin binding|
|methyltransferase activity|
|aorta development|
|photoreceptor cell differentiation|
|heart valve development|
|artery morphogenesis|
|regulation of alpha-beta T cell differentiation|
|maternal process involved in female pregnancy|
|chromatin DNA binding|
|ventricular septum development|
|artery development|
|embryonic placenta development|
|post-embryonic development|
|regulation of alpha-beta T cell activation|
|columnar/cuboidal epithelial cell differentiation|
|cardiac septum development|
|histone deacetylase binding|
|cardiac ventricle development|
|digestive tract development|
|regulation of T cell differentiation|
|digestive system development|
|eye morphogenesis|
|placenta development|
|morphogenesis of a branching structure|
|regulation of lymphocyte differentiation|
|cardiac chamber development|
|female pregnancy|
|epithelial cell development|
|multi-multicellular organism process|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cell fate commitment|
|sensory organ morphogenesis|
|germ cell development|
|regulation of leukocyte differentiation|
|methylation|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|regulation of T cell activation|
|cellular process involved in reproduction in multicellular organism|
|eye development|
|visual system development|
|sensory system development|
|in utero embryonic development|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|regulation of hemopoiesis|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|heart development|
|sensory organ development|
|cell population proliferation|
|regulation of leukocyte activation|
|adaptive immune response|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|gamete generation|
|innate immune response|
|neuron development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|defense response to other organism|
|animal organ morphogenesis|
|embryo development|
|multi-organism reproductive process|
|neuron differentiation|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|immune response|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.1|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.83|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.13|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9155
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDM1 Expression in NALM6 Cells: 0.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>