PRDX4 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= PRDX4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRDX4
  * **<color #00a2e8>Official Name</color>**: peroxiredoxin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10549|10549]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13162|Q13162]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRDX4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRDX4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300927|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:   The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I- kappa-B-alpha phosphorylation. {ECO:0000269|PubMed:9388242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AhpC-TSA|
|1-cysPrx C|
|Redoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of germ cell proliferation|
|negative regulation of male germ cell proliferation|
|regulation of germ cell proliferation|
|regulation of male germ cell proliferation|
|thioredoxin peroxidase activity|
|protein maturation by protein folding|
|I-kappaB phosphorylation|
|4-hydroxyproline metabolic process|
|hydrogen peroxide catabolic process|
|smooth endoplasmic reticulum|
|hydrogen peroxide metabolic process|
|antibiotic catabolic process|
|negative regulation of reproductive process|
|cofactor catabolic process|
|I-kappaB kinase/NF-kappaB signaling|
|cell redox homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|secretory granule lumen|
|ficolin-1-rich granule lumen|
|detoxification|
|male gonad development|
|development of primary male sexual characteristics|
|drug catabolic process|
|male sex differentiation|
|regulation of reproductive process|
|cellular modified amino acid metabolic process|
|gonad development|
|alpha-amino acid metabolic process|
|cellular response to toxic substance|
|negative regulation of multi-organism process|
|development of primary sexual characteristics|
|protein maturation|
|protein folding|
|sex differentiation|
|cellular amino acid metabolic process|
|extracellular matrix organization|
|response to oxidative stress|
|extracellular structure organization|
|reproductive structure development|
|reproductive system development|
|cofactor metabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|drug metabolic process|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|spermatogenesis|
|male gamete generation|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|gamete generation|
|regulated exocytosis|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|exocytosis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|protein homodimerization activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|leukocyte activation|
|oxidation-reduction process|
|protein phosphorylation|
|multi-organism reproductive process|
|oxoacid metabolic process|
|secretion by cell|
|endoplasmic reticulum|
|organic acid metabolic process|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|negative regulation of multicellular organismal process|
|phosphorylation|
|reproductive process|
|reproduction|
|regulation of cell population proliferation|
|homeostatic process|
|intracellular signal transduction|
|small molecule metabolic process|
|cellular catabolic process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10060
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRDX4 Expression in NALM6 Cells: 5.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>