PRKAR2B [The Human Chemical-Genetic Interaction Map Project]

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======= PRKAR2B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PRKAR2B
  * **<color #00a2e8>Official Name</color>**: protein kinase cAMP-dependent type II regulatory subunit beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5577|5577]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31323|P31323]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PRKAR2B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PRKAR2B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176912|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIIa|
|cNMP binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to clozapine|
|response to antipsychotic drug|
|cAMP-dependent protein kinase regulator activity|
|cAMP-dependent protein kinase inhibitor activity|
|negative regulation of cAMP-dependent protein kinase activity|
|cAMP-dependent protein kinase complex|
|protein kinase A catalytic subunit binding|
|3,5-cyclic-GMP phosphodiesterase activity|
|regulation of cAMP-dependent protein kinase activity|
|activation of protein kinase A activity|
|cAMP binding|
|cGMP-mediated signaling|
|cellular response to glucagon stimulus|
|renal water homeostasis|
|ciliary base|
|response to glucagon|
|dendritic shaft|
|multicellular organismal water homeostasis|
|water homeostasis|
|ciliary basal body-plasma membrane docking|
|renal system process|
|G2/M transition of mitotic cell cycle|
|negative regulation of protein serine/threonine kinase activity|
|cell cycle G2/M phase transition|
|learning|
|dendritic spine|
|organelle localization by membrane tethering|
|cyclic-nucleotide-mediated signaling|
|membrane docking|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|membrane raft|
|negative regulation of protein kinase activity|
|protein domain specific binding|
|negative regulation of kinase activity|
|learning or memory|
|cellular response to peptide hormone stimulus|
|mitotic cell cycle phase transition|
|negative regulation of transferase activity|
|cell cycle phase transition|
|blood coagulation|
|ubiquitin protein ligase binding|
|coagulation|
|hemostasis|
|cognition|
|response to xenobiotic stimulus|
|fatty acid metabolic process|
|multicellular organismal homeostasis|
|cellular response to peptide|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|cilium assembly|
|glutamatergic synapse|
|cilium organization|
|neuronal cell body|
|response to peptide hormone|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|negative regulation of phosphorylation|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|response to peptide|
|wound healing|
|centrosome|
|regulation of body fluid levels|
|regulation of protein serine/threonine kinase activity|
|monocarboxylic acid metabolic process|
|positive regulation of protein kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|response to wounding|
|positive regulation of kinase activity|
|organelle localization|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|regulation of cell cycle process|
|organelle assembly|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|response to hormone|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|regulation of transferase activity|
|cell cycle process|
|response to organonitrogen compound|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|response to drug|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|cell projection organization|
|regulation of cell cycle|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|cell cycle|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.01|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.72|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|2.11|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PRKAR2B Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>